2015
Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers
Esterhuyse M, Weiner J, Caron E, Loxton A, Iannaccone M, Wagman C, Saikali P, Stanley K, Wolski W, Mollenkopf H, Schick M, Aebersold R, Linhart H, Walzl G, Kaufmann S. Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers. MBio 2015, 6: 10.1128/mbio.01187-15. PMID: 26374119, PMCID: PMC4600108, DOI: 10.1128/mbio.01187-15.Peer-Reviewed Original ResearchConceptsTB patientsPilot studyActive tuberculosis diseaseLarge-scale studiesSpread of TBLTBI controlLTBI participantsTuberculosis infectionTuberculosis diseaseDisease progressionHealthy controlsPrognostic biomarkerImmune responseBiologic mechanismsHealthy individualsPatientsHost responseInfected individualsBetter careInfectious diseasesMycobacterium tuberculosisSmall sample sizeBiomarker developmentRegulation of functionDNA methylation
2005
Identification of two distinct intracellular localization signals in STT3-B
Caron É, Côté C, Parisien M, Major F, Perreault C. Identification of two distinct intracellular localization signals in STT3-B. Archives Of Biochemistry And Biophysics 2005, 445: 108-114. PMID: 16297371, DOI: 10.1016/j.abb.2005.10.007.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell LineChlorocebus aethiopsComputational BiologyConserved SequenceEndoplasmic ReticulumHumansIsoenzymesMembrane ProteinsMiceMicroscopy, Electron, TransmissionMolecular Sequence DataNuclear Localization SignalsPhylogenyProtein Structure, TertiaryRecombinant Fusion ProteinsSequence Homology, Amino AcidConceptsBipartite nuclear targeting sequenceRemarkable evolutionary conservationNuclear targeting sequenceN-glycosylation processIntracellular localization signalsC-terminal domainLast transmembrane segmentAmino acid sequenceSTT3 subunitEvolutionary conservationTargeting sequenceLocalization signalOligosaccharyltransferase complexTopogenic determinantsTransmembrane segmentsNucleolar localizationSTT3Reporter proteinTM segmentsTerminal tailAcid sequenceHomo sapiensLatter sequenceCritical roleSequence