D. S. Fahmeed Hyder, PhD
Professor of Radiology and Biomedical Imaging and of Biomedical EngineeringCards
About
Research
Overview
Specific areas of interest in functional imaging include (i) understanding the role of the extraordinarily high energy demands of ongoing and intrinsic activity within neural populations as potential for quantitative disease biomarker, (ii) advancing the spatiotemporal resolution of functional imaging to understand the relation of cellular metabolism in health and disease (e.g., healthy aging, Alzheimer’s disease, depression, epilepsy, schizophrenia), and (iii) developing advanced calibrated fMRI methods for using oxidative energy as an absolute index of neural activity, both with task and rest paradigms, across cortical and subcortical regions.
For molecular imaging we use a method called BIRDS, which we developed and quite unconventionally detects the paramagnetically-shifted and non-exchangeable protons from lanthanide (or transition) metal ion probes for high spatiotemporal resolution biosensing. Highly precise molecular imaging of temperature and pH is achievable with BIRDS. Current areas of relevance are (i) design of new molecular probes for BIRDS, (ii) early cancer detection and metastasis using absolute pH imaging, (iii) application of new probes for BIRDS as molecular targets for diseases (e.g., diabetes), and (iv) detection of tumor response to treatments (e.g., radiation, chemotherapy, heat).
Calibrated fMRI for basal metabolism – simulation studies to assess sensitivities required for fMRI and perfusion data to extract basal metabolism from calibrated fMRI data
Quantitative metabolic PET – analysis of whole brain PET data of glucose and oxidative metabolism in the human brain in relation to blood flow
Liposomal BIRDS – development and/or characterization of newly developed probes encapsulated inside liposomes for BIRDS
Dendrimeric BIRDS – development and/or characterization of newly developed macromolecular-based probes for BIRDS
Medical Subject Headings (MeSH)
Academic Achievements & Community Involvement
News & Links
Media
- Because the burden of misdiagnosed brain disorders and diseases is substantial, the Hyder lab is leading breakthroughs in quantitative and translational imaging technologies, based primarily on magnetic resonance methods, to visualize molecular processes of function and dysfunction at the laminar level of the mammalian brain.
- High resolution functional imaging. In vivo examples of fMRI for different rodent sensory models, where the colored voxels overlaid on top of the gray anatomy reflect sensory-induced function revealed by BOLD contrast. Courtesy of Basavaraju G. Sanganahalli and Christopher J. Bailey.
- High resolution anatomical imaging. In vivo example of high resolution DTI in rodent brain, where the yellow, pink, and green colors represent respective directional dominance of fractional anisotropy of water diffusion to reflect tissue microstructure. Courtesy of Daniel Coman and Basavaraju G. Sanganahalli.
- High resolution molecular imaging. Based on a platform of an ultra-fast chemical shift imaging method called BIRDS, where we detect paramagnetically-shifted non-exchangeable protons from chelated lanthanide (or transition) metal ion probes, examples of high resolution temperature maps in rodent brain are shown. Data from Coman et al (2013) NMR Biomed. 26:1589-1595.
- High resolution optical imaging of blood rheology. In vivo examples of laser speckle contrast leading to RBC velocity in rodent brain. The RBC velocity data are used to measure the rheological properties of BOLD contrast. Courtesy of Peter Herman.
- High resolution electrical imaging of local field potential (LFP) and multi-unit activity (MUA). In vivo example of a 6x6 electrode array recording of MUA and LFP in rodent brain during sensory stimulation. The arrows reveal spatial uncoupling between MUA and LFP which has relevance for physiological interpretation of BOLD contrast. Courtesy of Peter Herman.
News
- October 12, 2021
ADPKD is Reversible in Preclinical Models, Finds New Yale Study
- March 06, 2021Source: Yale News
Yale study finds that when smelling, oral stimuli are weaker than nasal stimuli
- February 11, 2021Source: YaleNews
Taste and Its Two Ways to the Brain
- September 11, 2019
Prof. Hyder Joins Interdisciplinary Team to Assess Stroke Treatments