2000
Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients
Petroff O, Hyder F, Rothman D, Mattson R. Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients. Epilepsia 2000, 41: 675-680. PMID: 10840398, DOI: 10.1111/j.1528-1157.2000.tb00227.x.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidFirst oral doseFirst doseOral doseAntiepileptic drugsEffect of gabapentinStandard daily doseSingle high doseGBP therapyDaily therapyNeuropathic painAnticonvulsant effectsFurther seizuresDaily doseEpilepsy patientsOccipital cortexHigh doseGabapentinPatientsPartial protectionDoseHomocarnosineTherapyVivo measurements
1998
Vigabatrin increases human brain homocarnosine and improves seizure control
Petroff O, Mattson R, Behar K, Hyder F, Rothman D. Vigabatrin increases human brain homocarnosine and improves seizure control. Annals Of Neurology 1998, 44: 948-952. PMID: 9851440, DOI: 10.1002/ana.410440614.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidSeizure controlGABA concentrationAddition of vigabatrinLow-dose vigabatrinImproved seizure controlMean GABA concentrationAntiepileptic drug vigabatrinInhibitory neuromodulatorDaily doseGABAergic neuronsGABA levelsLarge dosesHomocarnosine concentrationsVigabatrinDrug vigabatrinHomocarnosinePatientsHuman brainMagnetic resonance spectroscopyControlNeuromodulatorsNeuronsDoseDoses