2011
Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat
Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. Journal Of Neuroscience 2011, 31: 15053-15064. PMID: 22016539, PMCID: PMC3432284, DOI: 10.1523/jneurosci.0101-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingBrain WavesCerebral CortexCerebrovascular CirculationCorpus StriatumDisease Models, AnimalElectroencephalographyElectrophysiologyEpilepsyImage Processing, Computer-AssistedLaser-Doppler FlowmetryMagnetic Resonance ImagingNicotinic AntagonistsOxygenRatsRats, WistarThalamusTubocurarineVibrissaeConceptsCerebral blood flowCerebral blood volumeLocal field potentialsNeuronal activityLaser Doppler cerebral blood flowSubcortical structuresWAG/Rij ratsNeuronal activity decreasesHuman absence epilepsySpike-wave dischargesWAG/RijMultiunit activity recordingsFMRI signalsFunctional magnetic resonance imaging (fMRI) signalsMagnetic resonance imaging signalsFMRI decreasesCBF decreaseHemodynamic changesCerebral cortexBasal gangliaSomatosensory cortexAbsence epilepsyWhisker stimulationBlood flowAnimal models
2003
Neuroenergetic Basis of Functional MRI: Implications for Efficiency of Brain Work
Hyder F. Neuroenergetic Basis of Functional MRI: Implications for Efficiency of Brain Work. 2003, 73-74. DOI: 10.1109/nebc.2003.1215998.Peer-Reviewed Original ResearchNeural activityLocal energy metabolismEnergy metabolismActual neuronal activitiesNeuronal excitabilityRat brainBlood flowNeuronal activityExtracellular recordingsFunctional MRIBlood oxygenationSensory stimulationBlood vesselsOxidative metabolismNeuronal ensemblesMRI mapsFMRI signalsBrain workNeural basisMetabolismFMRIFMRI dataExcitabilityActivityBrain
2002
Quantitative fMRI of rat brain by multi-modal MRI and MRS measurements
Hyder F, Kida I, Smith A, Blumenfeld H, Shulman R, Rothman D. Quantitative fMRI of rat brain by multi-modal MRI and MRS measurements. International Congress Series 2002, 1235: 57-71. DOI: 10.1016/s0531-5131(02)00173-5.Peer-Reviewed Original ResearchMagnetic resonance imagingRat brainNeuronal activityFunctional MRIBOLD fMRI signalCerebral cortexNeuronal glucose oxidationRat cerebral cortexFunctional magnetic resonance imagingFMRI signalsBOLD functional MRIQuantitative magnetic resonance imagingBlood oxygenation levelBOLD fMRI studiesMulti-modal magnetic resonance imagingQuantitative functional MRIGlutamatergic neuronsOxygen deliveryPhysiologic basisResonance imagingPhysiologic componentsCMRO2BrainBlood circulationOxygenation level
2001
Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI
Hyder F, Kida I, Behar K, Kennan R, Maciejewski P, Rothman D. Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. NMR In Biomedicine 2001, 14: 413-431. PMID: 11746934, DOI: 10.1002/nbm.733.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingNeuronal activityBOLD functional MRIFunctional MRICerebral cortexPharmacological treatmentGlutamate release inhibitorNeuronal glucose oxidationRat cerebral cortexRelease of glutamateRat forepaw stimulation modelFMRI signalsFunctional magnetic resonance imagingQuantitative magnetic resonance imagingBlood oxygenation levelBOLD fMRI studiesEnergy metabolismBOLD fMRI signalMulti-modal magnetic resonance imagingGlutamatergic neuronsRelease inhibitorChannel blockersRat brainOxygen deliveryNeurochemical basis
1997
Functional MRI bold signal coincides with electrical activity in the rat whisker barrels
Yang X, Hyder F, Shulman R. Functional MRI bold signal coincides with electrical activity in the rat whisker barrels. Magnetic Resonance In Medicine 1997, 38: 874-877. PMID: 9402186, DOI: 10.1002/mrm.1910380604.Peer-Reviewed Original ResearchConceptsRat whisker barrelsElectrical activityFunctional MRIWhisker barrelsBlood oxygenation level-dependent (BOLD) image contrastBrain functional activityBOLD fMRI signalNeuronal electrical activitySustained stimulationFunctional activationNoninvasive methodFunctional activityFMRI signalsPerfusionRat whiskerLocalized increaseActivityMRI