2022
Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography
Mishra S, Herman P, Crair M, Constable R, Walsh J, Akif A, Verhagen J, Hyder F. Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography. Nanoscale 2022, 14: 17770-17788. PMID: 36437785, PMCID: PMC9850399, DOI: 10.1039/d2nr04878g.Peer-Reviewed Original ResearchConceptsProtein nanoparticlesParamagnetic iron oxide nanoparticlesIron oxide nanoparticlesMagnetic resonance imaging (MRI) contrastRelaxivity ratioOxide nanoparticlesRapid renal clearanceNanoparticlesMRI propertiesImaging contrastMRI contrastCitric acidNeuroscience applicationsFluorescent dyeBlood biochemical assaysUnambiguous detectionRelaxivityCerebral angiographyDyePlatformMajor blood vesselsBiochemical assaysTechnologyBrain capillariesFluorescence angiography
2015
Dendrimer-Based Responsive MRI Contrast Agents (G1–G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS)
Huang Y, Coman D, Hyder F, Ali MM. Dendrimer-Based Responsive MRI Contrast Agents (G1–G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS). Bioconjugate Chemistry 2015, 26: 2315-2323. PMID: 26497087, PMCID: PMC4784965, DOI: 10.1021/acs.bioconjchem.5b00568.Peer-Reviewed Original ResearchConceptsGn-PAMAMResponsive MRI contrast agentsNonexchangeable protonsRedundant deviationLigands/drugsChemical shift informationMRI contrast agentsMolecular imaging platformParamagnetic monomerModifiable surfaceBiocompatible macromoleculesContrast agentsDendrimersSurface modificationDrug deliveryModel dendrimersG2-PAMAMShift informationUnique propertiesTransverse relaxation timeTmDOTAFluorescent dyeMonomersMolecular imagingProminent signal