2001
Topiramate Rapidly Raises Brain GABA in Epilepsy Patients
Petroff O, Hyder F, Rothman D, Mattson R. Topiramate Rapidly Raises Brain GABA in Epilepsy Patients. Epilepsia 2001, 42: 543-548. PMID: 11440351, DOI: 10.1046/j.1528-1157.2001.18800.x.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnticonvulsantsBrain ChemistryCarnosineDose-Response Relationship, DrugDrug Administration ScheduleEpilepsy, Complex PartialFructoseGamma-Aminobutyric AcidHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyOccipital LobePyrrolidinonesStimulation, ChemicalTopiramateConceptsBrain GABAOral doseLong-term pharmacodynamic effectsFirst oral doseComplex partial seizuresTPM dosesTPM therapyFirst doseFurther seizuresPartial seizuresPharmacodynamic effectsEpilepsy patientsOccipital cortexPatientsGABAPartial protectionDoseFirst dayAcid metabolismDose responseHomocarnosineSeizuresVivo measurementsSurface coilTopiramate
1999
GABA Changes with Vigabatrin in the Developing Human Brain
Novotny E, Hyder F, Shevell M, Rothman D. GABA Changes with Vigabatrin in the Developing Human Brain. Epilepsia 1999, 40: 462-466. PMID: 10219272, DOI: 10.1111/j.1528-1157.1999.tb00741.x.Peer-Reviewed Original ResearchConceptsBrain GABA levelsGABA levelsBrain GABAVGB treatmentRole of GABASeizure controlGABA changesSeizure susceptibilityPediatric epilepsyEpileptic focusOccipital lobeNervous systemEpileptic regionsVigabatrinEpilepsyGABAGABA metabolismTreatmentAge 1Noninvasive measurementHuman brainSubjectsDrugsFivefold increaseChildren