2013
Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaRecurrent hypoglycemiaHypoglycemic conditionsIntensive insulin therapyTight glycemic controlType 2 diabetesInsulin therapyGlycemic controlBrain metabolismElevated lactateNeuronal metabolismRodent modelsNeuronal activityGlucose metabolismHypoglycemiaLactate uptakeNeuronal functionType 1Metabolic regulatorOxidative capacityModest incrementLactateMetabolismUnexpected findingBrain
2003
Neuroenergetic Basis of Functional MRI: Implications for Efficiency of Brain Work
Hyder F. Neuroenergetic Basis of Functional MRI: Implications for Efficiency of Brain Work. 2003, 73-74. DOI: 10.1109/nebc.2003.1215998.Peer-Reviewed Original ResearchNeural activityLocal energy metabolismEnergy metabolismActual neuronal activitiesNeuronal excitabilityRat brainBlood flowNeuronal activityExtracellular recordingsFunctional MRIBlood oxygenationSensory stimulationBlood vesselsOxidative metabolismNeuronal ensemblesMRI mapsFMRI signalsBrain workNeural basisMetabolismFMRIFMRI dataExcitabilityActivityBrain