2023
Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2
DiNuzzo M, Dienel G, Behar K, Petroff O, Benveniste H, Hyder F, Giove F, Michaeli S, Mangia S, Herculano‐Houzel S, Rothman D. Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2. Journal Of Neurochemistry 2023, 168: 632-662. PMID: 37150946, PMCID: PMC10628336, DOI: 10.1111/jnc.15839.Peer-Reviewed Original ResearchHigher cerebral blood flowCerebral blood flowOxygen extraction fractionNeurovascular couplingBlood flowLower oxygen extraction fractionNonoxidative glycolysisCerebral metabolic rateBrain pHCapillary densityNeurovascular diseasesNonoxidative metabolismTissue oxygenationHuman cortexBrain functionExtraction fractionBrain activationMitochondrial ATP productionPET measurementsCMROOxygen consumptionHomeostasisGlycogenolysisFMRI contrastActivationSpatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic waste
2016
Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI
Shu CY, Sanganahalli BG, Coman D, Herman P, Hyder F. Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI. Progress In Brain Research 2016, 225: 99-122. PMID: 27130413, DOI: 10.1016/bs.pbr.2016.02.003.Peer-Reviewed Original ResearchConceptsNeurovascular couplingFunctional MRINeuronal activityBlood oxygenation level-dependent (BOLD) signalFunctional brain activationLevel-dependent signalNeurometabolic couplingEffective therapyBlood flowNeuroimaging toolsHealth conditionsPowerful neuroimaging toolBrain activationBOLD signalNeural activityBOLD contrastMetabolic demandsOxygen consumptionDependent signalsTherapyMicrovesselsMRIActivityBiomarkers
2012
S Phase Entry of Neural Progenitor Cells Correlates with Increased Blood Flow in the Young Subventricular Zone
Lacar B, Herman P, Hartman NW, Hyder F, Bordey A. S Phase Entry of Neural Progenitor Cells Correlates with Increased Blood Flow in the Young Subventricular Zone. PLOS ONE 2012, 7: e31960. PMID: 22359646, PMCID: PMC3281100, DOI: 10.1371/journal.pone.0031960.Peer-Reviewed Original ResearchConceptsSubventricular zoneBlood flowNeural progenitor cellsAcute brain slice preparationGrowth factor injectionsProgenitor cellsReceptor agonist UIncreased blood flowBrain slice preparationSVZ cell proliferationCell proliferationLaser Doppler flowmetryLocal blood flowLocal hemodynamic responsesBasic fibroblast growth factorPostnatal subventricular zoneFibroblast growth factorAgonist UFactor injectionsVentricular injectionNeurovascular couplingAcute increaseSlice preparationDoppler flowmetryHemodynamic responseAnalysis of Time and Space Invariance of BOLD Responses in the Rat Visual System
Bailey CJ, Sanganahalli BG, Herman P, Blumenfeld H, Gjedde A, Hyder F. Analysis of Time and Space Invariance of BOLD Responses in the Rat Visual System. Cerebral Cortex 2012, 23: 210-222. PMID: 22298731, PMCID: PMC3513959, DOI: 10.1093/cercor/bhs008.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingGeneral linear modelingSuperior colliculusBOLD responseBasal blood flowNeural activityRat visual systemBlood oxygenation level-dependent (BOLD) responsePrimary visual cortexMagnetic resonance imagingLevel-dependent responsesNeurovascular couplingRat brainBlood flowVisual cortexResonance imagingStimulation paradigmV1 signalsLight flashesOnset/Neural signalsResponseV1Visual systemColliculus