Acute Effects of Vigabatrin on Brain GABA and Homocarnosine in Patients with Complex Partial Seizures
Petroff O, Hyder F, Collins T, Mattson R, Rothman D. Acute Effects of Vigabatrin on Brain GABA and Homocarnosine in Patients with Complex Partial Seizures. Epilepsia 1999, 40: 958-964. PMID: 10403220, DOI: 10.1111/j.1528-1157.1999.tb00803.x.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidDose of vigabatrinComplex partial seizuresPartial seizuresRefractory complex partial seizuresFirst oral doseVGB therapyFirst doseFurther seizuresAdjunct therapyDay dosingOral doseAcute effectsOral administrationOccipital cortexMedian increasePatientsVigabatrinChronic effectsNormal levelsPartial protectionSeizuresDoseHomocarnosineTopiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy
Petroff O, Hyder F, Mattson R, Rothman D. Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy. Neurology 1999, 52: 473-478. PMID: 10025774, DOI: 10.1212/wnl.52.3.473.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidComplex partial seizuresAntiepileptic actionPartial seizuresRefractory complex partial seizuresNew antiepileptic medicationsEffects of topiramateNew antiepileptic drugsDrug-free volunteersMultiple putative mechanismsPotent antiepileptic actionAntiepileptic medicationsAdditional patientsAntiepileptic drugsControl subjectsOccipital cortexTopiramatePatientsPutative mechanismsHomocarnosineEpilepsySeizuresVivo measurementsSurface coil