2016
Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI
Shu CY, Sanganahalli BG, Coman D, Herman P, Hyder F. Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI. Progress In Brain Research 2016, 225: 99-122. PMID: 27130413, DOI: 10.1016/bs.pbr.2016.02.003.Peer-Reviewed Original ResearchConceptsNeurovascular couplingFunctional MRINeuronal activityBlood oxygenation level-dependent (BOLD) signalFunctional brain activationLevel-dependent signalNeurometabolic couplingEffective therapyBlood flowNeuroimaging toolsHealth conditionsPowerful neuroimaging toolBrain activationBOLD signalNeural activityBOLD contrastMetabolic demandsOxygen consumptionDependent signalsTherapyMicrovesselsMRIActivityBiomarkersImaging the intratumoral–peritumoral extracellular pH gradient of gliomas
Coman D, Huang Y, Rao JU, De Feyter HM, Rothman DL, Juchem C, Hyder F. Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas. NMR In Biomedicine 2016, 29: 309-319. PMID: 26752688, PMCID: PMC4769673, DOI: 10.1002/nbm.3466.Peer-Reviewed Original ResearchConceptsRG2 tumorsTumor typesKi-67-positive cellsCancer therapeutic responseAcidic pHeTherapeutic responseRat brainPositive cellsSolid tumorsTumor cell invasionTumor borderTumorsPeritumoral regionNormal tissuesCell invasionTumor pHeP-MRSCancer imagingNeutral intracellularImagingPreclinical applicationsInfusionTherapy
2000
Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients
Petroff O, Hyder F, Rothman D, Mattson R. Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients. Epilepsia 2000, 41: 675-680. PMID: 10840398, DOI: 10.1111/j.1528-1157.2000.tb00227.x.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidFirst oral doseFirst doseOral doseAntiepileptic drugsEffect of gabapentinStandard daily doseSingle high doseGBP therapyDaily therapyNeuropathic painAnticonvulsant effectsFurther seizuresDaily doseEpilepsy patientsOccipital cortexHigh doseGabapentinPatientsPartial protectionDoseHomocarnosineTherapyVivo measurements