2001
Topiramate Rapidly Raises Brain GABA in Epilepsy Patients
Petroff O, Hyder F, Rothman D, Mattson R. Topiramate Rapidly Raises Brain GABA in Epilepsy Patients. Epilepsia 2001, 42: 543-548. PMID: 11440351, DOI: 10.1046/j.1528-1157.2001.18800.x.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnticonvulsantsBrain ChemistryCarnosineDose-Response Relationship, DrugDrug Administration ScheduleEpilepsy, Complex PartialFructoseGamma-Aminobutyric AcidHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyOccipital LobePyrrolidinonesStimulation, ChemicalTopiramateConceptsBrain GABAOral doseLong-term pharmacodynamic effectsFirst oral doseComplex partial seizuresTPM dosesTPM therapyFirst doseFurther seizuresPartial seizuresPharmacodynamic effectsEpilepsy patientsOccipital cortexPatientsGABAPartial protectionDoseFirst dayAcid metabolismDose responseHomocarnosineSeizuresVivo measurementsSurface coilTopiramate
2000
Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients
Petroff O, Hyder F, Rothman D, Mattson R. Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients. Epilepsia 2000, 41: 675-680. PMID: 10840398, DOI: 10.1111/j.1528-1157.2000.tb00227.x.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidFirst oral doseFirst doseOral doseAntiepileptic drugsEffect of gabapentinStandard daily doseSingle high doseGBP therapyDaily therapyNeuropathic painAnticonvulsant effectsFurther seizuresDaily doseEpilepsy patientsOccipital cortexHigh doseGabapentinPatientsPartial protectionDoseHomocarnosineTherapyVivo measurements
1999
Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy
Petroff O, Hyder F, Mattson R, Rothman D. Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy. Neurology 1999, 52: 473-478. PMID: 10025774, DOI: 10.1212/wnl.52.3.473.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidComplex partial seizuresAntiepileptic actionPartial seizuresRefractory complex partial seizuresNew antiepileptic medicationsEffects of topiramateNew antiepileptic drugsDrug-free volunteersMultiple putative mechanismsPotent antiepileptic actionAntiepileptic medicationsAdditional patientsAntiepileptic drugsControl subjectsOccipital cortexTopiramatePatientsPutative mechanismsHomocarnosineEpilepsySeizuresVivo measurementsSurface coil