2022
Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type
O’Connor D, Mandino F, Shen X, Horien C, Ge X, Herman P, Hyder F, Crair M, Papademetris X, Lake E, Constable. Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type. NeuroImage 2022, 264: 119735. PMID: 36347441, PMCID: PMC9808917, DOI: 10.1016/j.neuroimage.2022.119735.Peer-Reviewed Original Research
2013
Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels
Hyder F, Rothman DL, Bennett MR. Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3549-3554. PMID: 23319606, PMCID: PMC3587194, DOI: 10.1073/pnas.1214912110.Peer-Reviewed Original ResearchConceptsGlucose oxidation ratesCerebral cortexNeuronal activityActivity levelsGlucose metabolic dataHuman cerebral cortexMetabolic dataOxidative demandAwake valuesCortical neuronsSynaptic transmissionGlucose metabolismAwake stateSensory stimulationAnatomic dataRatsCortexMammalian speciesIsoelectricityMagnetic resonance spectroscopy resultsSignaling requirementsAstrocytesCell membraneLevelsNeuronsGlutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy
Hyder F, Fulbright RK, Shulman RG, Rothman DL. Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy. Cerebrovascular And Brain Metabolism Reviews 2013, 33: 339-347. PMID: 23299240, PMCID: PMC3587823, DOI: 10.1038/jcbfm.2012.207.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance spectroscopy studyAwake resting stateFuture clinical investigationsMagnetic resonance imagingHigh resting activityAwake human brainGray matter regionsGlutamatergic functionGlutamatergic signalingMetabolic measuresClinical investigationAwake stateResting activityVisual cortexGlucose utilizationResonance imaging