2016
Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas
Coman D, Huang Y, Rao JU, De Feyter HM, Rothman DL, Juchem C, Hyder F. Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas. NMR In Biomedicine 2016, 29: 309-319. PMID: 26752688, PMCID: PMC4769673, DOI: 10.1002/nbm.3466.Peer-Reviewed Original ResearchConceptsRG2 tumorsTumor typesKi-67-positive cellsCancer therapeutic responseAcidic pHeTherapeutic responseRat brainPositive cellsSolid tumorsTumor cell invasionTumor borderTumorsPeritumoral regionNormal tissuesCell invasionTumor pHeP-MRSCancer imagingNeutral intracellularImagingPreclinical applicationsInfusionTherapy
2015
Dendrimer-Based Responsive MRI Contrast Agents (G1–G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS)
Huang Y, Coman D, Hyder F, Ali MM. Dendrimer-Based Responsive MRI Contrast Agents (G1–G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS). Bioconjugate Chemistry 2015, 26: 2315-2323. PMID: 26497087, PMCID: PMC4784965, DOI: 10.1021/acs.bioconjchem.5b00568.Peer-Reviewed Original ResearchMeSH KeywordsBiosensing TechniquesContrast MediaDendrimersMagnetic Resonance ImagingOrganometallic CompoundsThuliumConceptsGn-PAMAMResponsive MRI contrast agentsNonexchangeable protonsRedundant deviationLigands/drugsChemical shift informationMRI contrast agentsMolecular imaging platformParamagnetic monomerModifiable surfaceBiocompatible macromoleculesContrast agentsDendrimersSurface modificationDrug deliveryModel dendrimersG2-PAMAMShift informationUnique propertiesTransverse relaxation timeTmDOTAFluorescent dyeMonomersMolecular imagingProminent signal
2014
Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS)
Maritim S, Huang Y, Coman D, Hyder F. Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS). JBIC Journal Of Biological Inorganic Chemistry 2014, 19: 1385-1398. PMID: 25304046, PMCID: PMC4348029, DOI: 10.1007/s00775-014-1200-z.Peer-Reviewed Original ResearchMeSH KeywordsBiosensing TechniquesContrast MediaCoordination ComplexesLanthanoid Series ElementsLiposomesMagnetic Resonance ImagingMolecular ImagingMolecular StructureConceptsLanthanide complexesMagnetic resonance imaging (MRI) probesParamagnetic lanthanide complexesT2 contrast agentsRedundant deviationMolecular imagingMRI contrast agentsNon-exchangeable protonsContrast agentsMRI contrastChemical shiftsMRI probesLiposomal encapsulation efficiencyParamagnetic environmentSignal amplificationEncapsulation efficiencyWater relaxationProbe environmentTransverse relaxation timeParamagnetic effectImaging probeHigh spatial resolutionParamagnetic agentsParamagnetic contrast agentRelaxation time
2013
In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution
Coman D, de Graaf R, Rothman DL, Hyder F. In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution. NMR In Biomedicine 2013, 26: 1589-1595. PMID: 23881869, PMCID: PMC3800475, DOI: 10.1002/nbm.2995.Peer-Reviewed Original ResearchConceptsK-spaceNonexchanging protonsThree-dimensional molecular imagingParamagnetic lanthanide ionsRedundant deviationChemical shift imagingField of viewMolecular imaging capabilitiesMolecular imagingRapid data acquisitionProton detectionLanthanide ionsTens of minutesImaging capabilitiesMacrocyclic chelatesSpectroscopic signalsMacrocyclicCSI experimentsRelaxation timeHigh spatiotemporal resolutionParamagnetic agents
2011
A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA–tetraglycinate
Coman D, Kiefer GE, Rothman DL, Sherry AD, Hyder F. A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA–tetraglycinate. NMR In Biomedicine 2011, 24: 1216-1225. PMID: 22020775, PMCID: PMC3267016, DOI: 10.1002/nbm.1677.Peer-Reviewed Original ResearchMeSH KeywordsBiosensing TechniquesCoordination ComplexesEuropiumMagnetic Resonance ImagingPhantoms, ImagingTemperatureTime FactorsConceptsResponsive contrast agentsChemical exchange saturation transferMolecular imagingNonexchangeable proton resonancesMolecular imaging agentsLanthanide complexesCEST characteristicsIon complexesBiosensing propertiesBulk waterProton exchangeProton resonancesTetraacetate derivativeNonexchangeable protonsQuantitative molecular imagingRedundant deviationExchangeable sitesInner sphereSaturation transferImaging agentCEST methodComplexesIonsContrast agentsGreat potential
2010
Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): comparison between TmDOTP5−and TmDOTMA−
Coman D, Trubel HK, Hyder F. Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): comparison between TmDOTP5−and TmDOTMA−. NMR In Biomedicine 2010, 23: 277-285. PMID: 19957287, PMCID: PMC2843767, DOI: 10.1002/nbm.1461.Peer-Reviewed Original Research