Intranasal epidermal growth factor treatment rescues neonatal brain injury
Scafidi J, Hammond TR, Scafidi S, Ritter J, Jablonska B, Roncal M, Szigeti-Buck K, Coman D, Huang Y, McCarter RJ, Hyder F, Horvath TL, Gallo V. Intranasal epidermal growth factor treatment rescues neonatal brain injury. Nature 2013, 506: 230-234. PMID: 24390343, PMCID: PMC4106485, DOI: 10.1038/nature12880.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntranasalAnimalsAnimals, NewbornBrain InjuriesCell DifferentiationCell DivisionCell LineageCell SurvivalDemyelinating DiseasesDisease Models, AnimalEpidermal Growth FactorErbB ReceptorsHumansHypoxiaInfant, Premature, DiseasesMaleMiceMolecular Targeted TherapyOligodendrogliaRegenerationSignal TransductionStem CellsTime FactorsConceptsDiffuse white matter injuryNeonatal brain injuryVery preterm infantsWhite matter injuryOligodendrocyte precursor cellsEpidermal growth factor receptorGrowth factor treatmentGrowth factor receptorPreterm infantsFunctional recoveryBrain injurySuch injuriesEpidermal growth factor treatmentMouse modelFactor treatmentInjuryFactor receptorPrecursor cellsInfantsReceptorsCortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels
Hyder F, Rothman DL, Bennett MR. Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3549-3554. PMID: 23319606, PMCID: PMC3587194, DOI: 10.1073/pnas.1214912110.Peer-Reviewed Original ResearchConceptsGlucose oxidation ratesCerebral cortexNeuronal activityActivity levelsGlucose metabolic dataHuman cerebral cortexMetabolic dataOxidative demandAwake valuesCortical neuronsSynaptic transmissionGlucose metabolismAwake stateSensory stimulationAnatomic dataRatsCortexMammalian speciesIsoelectricityMagnetic resonance spectroscopy resultsSignaling requirementsAstrocytesCell membraneLevelsNeurons