2014
Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity
Lin AL, Coman D, Jiang L, Rothman DL, Hyder F. Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1440-1443. PMID: 24984898, PMCID: PMC4158670, DOI: 10.1038/jcbfm.2014.114.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsCaloric RestrictionGlutamic AcidGlutamineMaleMitochondriaRatsRats, Inbred F344Synaptic TransmissionConceptsOld CR ratsNeuronal activityYoung controlsCR ratsCaloric restriction (CR) prolongs lifespanHealthy agingNeuronal glucose oxidationBrain mitochondrial functionNeuronal energy productionMitochondrial functionAge-related declineNeurotransmitter cyclingOlder controlsNeurotransmission ratesBrain physiologyRatsGlucose oxidationProlong lifespanVivo nuclear magnetic resonance (NMR) spectroscopyMagnetic resonance spectroscopyDetrimental effectsAgingControl
2001
Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging
Shulman R, Hyder F, Rothman D. Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6417-6422. PMID: 11344262, PMCID: PMC33483, DOI: 10.1073/pnas.101129298.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainEnergy MetabolismGlutamic AcidGlycogenModels, NeurologicalNeuronsNeurotransmitter AgentsConceptsLactate concentrationBrain activationBrain lactate concentrationCerebral blood flowAdult mammalian brainBasal glucose oxidationPositron emission tomographyGlucose oxidationGlucose indexCerebral energeticsFunctional imaging dataNeurophysiological valuesBlood flowGlucose metabolismNeurotransmitter clearanceNeurochemical basisLactate effluxMammalian brainBasal physiological conditionsNeurotransmitter releaseAnaerobic glucose metabolismFunctional imagingComplete dataBrain activityMetabolic consumption rateInhibition of Voltage-Dependent Sodium Channels Suppresses the Functional Magnetic Resonance Imaging Response to Forepaw Somatosensory Activation in the Rodent
Kida I, Hyder F, Behar K. Inhibition of Voltage-Dependent Sodium Channels Suppresses the Functional Magnetic Resonance Imaging Response to Forepaw Somatosensory Activation in the Rodent. Cerebrovascular And Brain Metabolism Reviews 2001, 21: 585-591. PMID: 11333369, DOI: 10.1097/00004647-200105000-00013.Peer-Reviewed Original ResearchConceptsMagnetic resonance imaging responseSomatosensory activationFunctional magnetic resonance imaging (fMRI) responsesForepaw stimulationLamotrigine treatmentImaging responseGlutamate release inhibitorBOLD fMRI responsesFunctional imaging signalsBOLD fMRI signal changesFMRI signal changesTime-dependent mannerBaseline CBFAbsence of stimulationSomatosensory cortexRelease inhibitorChannel blockersRat cortexNeurotransmitter cycleBlood flow experimentsFMRI responsesBOLD fMRIStimulationLamotrigineTreatmentWhat you see is what you think – or is it?
Pellerin L, Sibson N, Hadjikhani N, Hyder F. What you see is what you think – or is it? Trends In Neurosciences 2001, 24: 71-72. PMID: 11252265, DOI: 10.1016/s0166-2236(00)01715-x.Peer-Reviewed Original Research
1999
In vivo carbon‐edited detection with proton echo‐planar spectroscopic imaging (ICED PEPSI): [3,4‐13CH2]glutamate/glutamine tomography in rat brain
Hyder F, Renken R, Rothman D. In vivo carbon‐edited detection with proton echo‐planar spectroscopic imaging (ICED PEPSI): [3,4‐13CH2]glutamate/glutamine tomography in rat brain. Magnetic Resonance In Medicine 1999, 42: 997-1003. PMID: 10571918, DOI: 10.1002/(sici)1522-2594(199912)42:6<997::aid-mrm1>3.0.co;2-1.Peer-Reviewed Original ResearchIn vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics
Rothman D, Sibson N, Hyder F, Shen J, Behar K, Shulman R. In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 1165-1177. PMID: 10466144, PMCID: PMC1692640, DOI: 10.1098/rstb.1999.0472.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGlutamate-glutamine cycleNerve terminalsNeurotransmitter cycleGlucose metabolismBlood oxygenation level-dependent magnetic resonance imagingLevel-dependent magnetic resonance imagingBrain glucose oxidationCortical glucose metabolismMagnetic resonance spectroscopy studyCortex of ratsMagnetic resonance imagingFunctional imaging studiesSpecific neuronal activityOxidative glucose metabolismGlial cellsNeuronal activityResonance imagingImaging studiesHuman cortexBrain functionBrain activityRatsCortexGlucose oxidationGlutamate