2014
Insights from Neuroenergetics into the Interpretation of Functional Neuroimaging: An Alternative Empirical Model for Studying the Brain's Support of Behavior
Shulman RG, Hyder F, Rothman DL. Insights from Neuroenergetics into the Interpretation of Functional Neuroimaging: An Alternative Empirical Model for Studying the Brain's Support of Behavior. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1721-1735. PMID: 25160670, PMCID: PMC4269754, DOI: 10.1038/jcbfm.2014.145.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingNeuronal activityMental moduleObservable behaviorBrain activityDistinct psychological mechanismsResonance imagingBaseline neuronal activityPositron emission tomography (PET) imagingEmission Tomography ImagingPsychological mechanismsMental processesFunctional neuroimagingBrain supportAwake humansAlternative empirical modelsNeurophysiological parametersBaseline activityTomography imagingTheoretical assumptionsSensory systemsIncremental signalNeuroimagingElectrical recordings
2013
Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI
Herman P, Sanganahalli BG, Blumenfeld H, Rothman DL, Hyder F. Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 15115-15120. PMID: 23980158, PMCID: PMC3773779, DOI: 10.1073/pnas.1307154110.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood VolumeCerebrovascular CirculationFunctional NeuroimagingMagnetic Resonance ImagingModels, NeurologicalOxygenRatsSomatosensory CortexConceptsCerebral blood volumeLocal field potentialsMultiunit activitySomatosensory cortexCortical laminaeBlood oxygenation level-dependent (BOLD) signalRat somatosensory cortexLevel-dependent signalNeurometabolic couplingCerebral cortexSuperficial laminaeCBF changesDeep laminaeMagnetic resonance imaging dataBlood flowQuantitative neuroimagingBlood volumeFunctional MRISensory stimulationBOLD signalOxidative metabolismCortexLayer-specific responsesMetabolic measurementsField potentials
2009
Cerebral oxygen demand for short‐lived and steady‐state events
Herman P, Sanganahalli BG, Blumenfeld H, Hyder F. Cerebral oxygen demand for short‐lived and steady‐state events. Journal Of Neurochemistry 2009, 109: 73-79. PMID: 19393011, PMCID: PMC2714475, DOI: 10.1111/j.1471-4159.2009.05844.x.Peer-Reviewed Original Research
2001
Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging
Shulman R, Hyder F, Rothman D. Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6417-6422. PMID: 11344262, PMCID: PMC33483, DOI: 10.1073/pnas.101129298.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainEnergy MetabolismGlutamic AcidGlycogenModels, NeurologicalNeuronsNeurotransmitter AgentsConceptsLactate concentrationBrain activationBrain lactate concentrationCerebral blood flowAdult mammalian brainBasal glucose oxidationPositron emission tomographyGlucose oxidationGlucose indexCerebral energeticsFunctional imaging dataNeurophysiological valuesBlood flowGlucose metabolismNeurotransmitter clearanceNeurochemical basisLactate effluxMammalian brainBasal physiological conditionsNeurotransmitter releaseAnaerobic glucose metabolismFunctional imagingComplete dataBrain activityMetabolic consumption rate
2000
Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study
Hyder F, Kennan R, Kida I, Mason G, Behar K, Rothman D. Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 485-498. PMID: 10724113, DOI: 10.1097/00004647-200003000-00007.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCapillary bedOxygen deliveryML xCerebral oxygen deliveryNicotine hydrogen tartrateRespective control conditionsValues of CBFMorphine anesthesiaSensorimotor cortexForepaw stimulationSodium pentobarbitalRat brainBlood flowCMRO2Mature ratsCortical activityResonance imagingBasal conditionsPercentage changeRatsAdministrationCBF
1999
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics
Rothman D, Sibson N, Hyder F, Shen J, Behar K, Shulman R. In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 1165-1177. PMID: 10466144, PMCID: PMC1692640, DOI: 10.1098/rstb.1999.0472.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGlutamate-glutamine cycleNerve terminalsNeurotransmitter cycleGlucose metabolismBlood oxygenation level-dependent magnetic resonance imagingLevel-dependent magnetic resonance imagingBrain glucose oxidationCortical glucose metabolismMagnetic resonance spectroscopy studyCortex of ratsMagnetic resonance imagingFunctional imaging studiesSpecific neuronal activityOxidative glucose metabolismGlial cellsNeuronal activityResonance imagingImaging studiesHuman cortexBrain functionBrain activityRatsCortexGlucose oxidationGlutamate