2009
Programming cells by multiplex genome engineering and accelerated evolution
Wang HH, Isaacs FJ, Carr PA, Sun ZZ, Xu G, Forest CR, Church GM. Programming cells by multiplex genome engineering and accelerated evolution. Nature 2009, 460: 894-898. PMID: 19633652, PMCID: PMC4590770, DOI: 10.1038/nature08187.Peer-Reviewed Original Research
2003
Prediction and measurement of an autoregulatory genetic module
Isaacs FJ, Hasty J, Cantor CR, Collins JJ. Prediction and measurement of an autoregulatory genetic module. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 7714-7719. PMID: 12808135, PMCID: PMC164653, DOI: 10.1073/pnas.1332628100.Peer-Reviewed Original ResearchConceptsGene regulatory networksGenetic modulesGene networksRegulatory networksComplex gene regulatory networksPhenotypic cellular responsesAutoregulatory gene networksStochastic versionCellular processesExpression statesProtein destabilizationCellular controlModel fluctuationsGene expressionSystems biologyCellular responsesProper quantitative descriptionQuantitative agreementSuch networksInternal noiseQuantitative descriptionQuantitative understandingKey propertiesPopulation distributionExperimental validation