2020
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma
Hegde M, Joseph SK, Pashankar F, DeRenzo C, Sanber K, Navai S, Byrd TT, Hicks J, Xu ML, Gerken C, Kalra M, Robertson C, Zhang H, Shree A, Mehta B, Dakhova O, Salsman VS, Grilley B, Gee A, Dotti G, Heslop HE, Brenner MK, Wels WS, Gottschalk S, Ahmed N. Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma. Nature Communications 2020, 11: 3549. PMID: 32669548, PMCID: PMC7363864, DOI: 10.1038/s41467-020-17175-8.Peer-Reviewed Original ResearchConceptsHER2-CAR T cellsCAR T cellsT-cell infusionCAR T-cell infusionT cellsMetastatic rhabdomyosarcomaOngoing phase I trialPhase I trialT cell receptorSecond remissionI trialSerum autoantibodiesImmune reactivityDetectable diseaseTumor responseBone marrowResponse consolidationInfusionRhabdomyosarcomaImmunodominant clonesLymphodepletionRemissionPathway proteinsDiseaseMonths
2001
Successful Chemotherapeutic Decompression of Primary Endodermal Sinus Tumor Presenting With Severe Spinal Cord Compression
Pashankar F, Steinbok P, Blair G, Pritchard S. Successful Chemotherapeutic Decompression of Primary Endodermal Sinus Tumor Presenting With Severe Spinal Cord Compression. Journal Of Pediatric Hematology/Oncology 2001, 23: 170-173. PMID: 11305721, DOI: 10.1097/00043426-200103000-00010.Peer-Reviewed Original ResearchConceptsEndodermal sinus tumorSpinal cord compressionCord compressionRadiation therapySevere spinal cord compressionEpidural cord compressionExcellent tumor responseComplete neurologic recoveryCisplatin-based chemotherapyNeurologic recoverySinus tumorComplete paraplegiaTumor PresentingTumor responseRapid resolutionLaminectomyChemotherapyTherapyChildren