2020
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma
Hegde M, Joseph SK, Pashankar F, DeRenzo C, Sanber K, Navai S, Byrd TT, Hicks J, Xu ML, Gerken C, Kalra M, Robertson C, Zhang H, Shree A, Mehta B, Dakhova O, Salsman VS, Grilley B, Gee A, Dotti G, Heslop HE, Brenner MK, Wels WS, Gottschalk S, Ahmed N. Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma. Nature Communications 2020, 11: 3549. PMID: 32669548, PMCID: PMC7363864, DOI: 10.1038/s41467-020-17175-8.Peer-Reviewed Original ResearchConceptsHER2-CAR T cellsCAR T cellsT-cell infusionCAR T-cell infusionT cellsMetastatic rhabdomyosarcomaOngoing phase I trialPhase I trialT cell receptorSecond remissionI trialSerum autoantibodiesImmune reactivityDetectable diseaseTumor responseBone marrowResponse consolidationInfusionRhabdomyosarcomaImmunodominant clonesLymphodepletionRemissionPathway proteinsDiseaseMonths
2015
Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration
Olson TA, Murray MJ, Rodriguez-Galindo C, Nicholson JC, Billmire DF, Krailo MD, Dang HM, Amatruda JF, Thornton CM, Arul GS, Stoneham SJ, Pashankar F, Stark D, Shaikh F, Gershenson DM, Covens A, Hurteau J, Stenning SP, Feldman DR, Grimison PS, Huddart RA, Sweeney C, Powles T, Lopes LF, dos Santos Agular S, Chinnaswamy G, Khaleel S, Abouelnaga S, Hale JP, Frazier AL. Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration. Journal Of Clinical Oncology 2015, 33: 3018-3028. PMID: 26304902, PMCID: PMC4979195, DOI: 10.1200/jco.2014.60.5337.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetChildCooperative BehaviorDiffusion of InnovationFemaleHistory, 20th CenturyHistory, 21st CenturyHumansInterdisciplinary CommunicationInternational CooperationMaleMedical OncologyNeoplasms, Germ Cell and EmbryonalPediatricsSurvivorsTime FactorsTreatment OutcomeYoung AdultConceptsGerm cell tumorsPrimary tumor siteCell tumorsExtracranial malignant germ cell tumorsExtracranial germ cell tumorsTumor siteMalignant germ cell tumorsSignificant long-term morbidityDifferent risk stratificationLong-term morbidityPlatinum-based chemotherapyPediatric cancer patientsTreatment-related effectsDifferent cooperative groupsCisplatin dosingVariety of specialistsMedical oncologistsGynecologic oncologistsRisk stratificationTherapeutic dilemmaHistologic featuresPediatric oncologistsExcellent outcomesStaging systemCancer patients
2014
Rituximab for the Treatment of Acute Refractory ITP
Kim SG, Whyte D, Pashankar FD. Rituximab for the Treatment of Acute Refractory ITP. Journal Of Pediatric Hematology/Oncology 2014, 36: e149-e151. PMID: 23669737, DOI: 10.1097/mph.0b013e318292f006.Peer-Reviewed Original ResearchConceptsRefractory immune thrombocytopenic purpuraImmune thrombocytopenic purpuraFirst-line therapyTreatment of ITPAcute immune thrombocytopenic purpuraSecond-line therapySustained remissionIntravenous immunoglobulinIntravenous rituximabEffective regimenImmune globulinAcute settingThrombocytopenic purpuraCombined therapyRituximabMost childrenTherapyClear consensusTreatmentCorticosteroidsRemissionPurpuraRegimenPatientsImmunoglobulinSurveillance After Initial Surgery for Pediatric and Adolescent Girls With Stage I Ovarian Germ Cell Tumors: Report From the Children's Oncology Group
Billmire DF, Cullen JW, Rescorla FJ, Davis M, Schlatter MG, Olson TA, Malogolowkin MH, Pashankar F, Villaluna D, Krailo M, Egler RA, Rodriguez-Galindo C, Frazier AL. Surveillance After Initial Surgery for Pediatric and Adolescent Girls With Stage I Ovarian Germ Cell Tumors: Report From the Children's Oncology Group. Journal Of Clinical Oncology 2014, 32: 465-470. PMID: 24395845, PMCID: PMC4876316, DOI: 10.1200/jco.2013.51.1006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlpha-FetoproteinsAntineoplastic Combined Chemotherapy ProtocolsBleomycinChildChild, PreschoolCisplatinDisease-Free SurvivalEtoposideFemaleHumansInfantInfant, NewbornKaplan-Meier EstimateNeoplasm Recurrence, LocalNeoplasm StagingNeoplasm, ResidualNeoplasms, Germ Cell and EmbryonalOvarian NeoplasmsRadiographyRisk FactorsSalvage TherapyTime FactorsTreatment OutcomeConceptsMalignant ovarian germ cell tumorsStage I malignant ovarian germ cell tumorsOvarian germ cell tumorsEvent-free survivalGerm cell tumorsOverall survivalAlpha-fetoproteinRecurrent diseaseOncology GroupCell tumorsSuccessful Salvage ChemotherapyTumor marker elevationPercent of patientsKaplan-Meier methodChildren's Oncology GroupSerum tumor markersPredominant histologySalvage chemotherapyInitial surgeryMarker elevationMetastatic diseaseSurgical resectionMedian timeYolk sacTumor markers
2005
MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use.
Pashankar FD, O'Dorisio MS, Menda Y. MIBG and somatostatin receptor analogs in children: current concepts on diagnostic and therapeutic use. Journal Of Nuclear Medicine 2005, 46 Suppl 1: 55s-61s. PMID: 15653652.Peer-Reviewed Original ResearchMeSH Keywords3-IodobenzylguanidineAnimalsChildChild, PreschoolClinical Trials as TopicHumansInfantInfant, NewbornNeuroblastomaOctreotidePatient SelectionPentetic AcidPractice Guidelines as TopicPractice Patterns, Physicians'Radiation InjuriesRadionuclide ImagingRadiopharmaceuticalsSomatostatinTreatment OutcomeConceptsSolid tumorsCertain pediatric tumorsSomatostatin receptor analoguesPediatric solid tumorsMetaiodobenzylguanidine scanNuclear imaging techniquesBone scanPediatric tumorsFalse transmitterTherapeutic useCell membrane receptorsReceptor analoguesYoung adultsTumorsMolecular targetsCurrent conceptsMIBGScansMembrane receptorsSpecific ligandsImaging techniquesChildrenSubcellular organellesCellular proteinsDiagnosis