Intact T cell responses in ataxia telangiectasia
Pashankar F, Singhal V, Akabogu I, Gatti RA, Goldman FD. Intact T cell responses in ataxia telangiectasia. Clinical Immunology 2006, 120: 156-162. PMID: 16762595, DOI: 10.1016/j.clim.2006.04.568.Peer-Reviewed Original ResearchConceptsAtaxia telangiectasiaSingle-cell levelQuantitative real-time PCRReal-time PCRT patientsRecessive multisystem disorderOpportunistic infectionsCell functionT cellsAutosomal recessive multisystem disorderCell levelIntact T-cell responsesCD8 T cell subsetsSignificant immune abnormalitiesLevels of Th1T cell responsesT cell subsetsVariable immune deficiencyT cell functionFlow cytometryAnti-CD3 stimulationStimulated T cellsQuantitative defectsCellsImmune abnormalities