2005
Triplex-forming oligonucleotides as potential tools for modulation of gene expression.
Rogers FA, Lloyd JA, Glazer PM. Triplex-forming oligonucleotides as potential tools for modulation of gene expression. Anti-Cancer Agents In Medicinal Chemistry 2005, 5: 319-26. PMID: 16101484, DOI: 10.2174/1568011054222300.Peer-Reviewed Original ResearchConceptsGene expressionAltered helical structureTarget sequenceSequence-specific mannerGenome modificationGenomic modificationsRepair pathwaysDNA-reactive compoundsOligonucleotide bindsDuplex DNAMajor grooveSpecific sitesHelical structureDual roleExpressionPossible roleCancer therapySequenceTFOGenomeTriplexesPolypyrimidineNumber of studiesDNABinds
2002
Site-directed recombination via bifunctional PNA–DNA conjugates
Rogers FA, Vasquez KM, Egholm M, Glazer PM. Site-directed recombination via bifunctional PNA–DNA conjugates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 16695-16700. PMID: 12461167, PMCID: PMC139206, DOI: 10.1073/pnas.262556899.Peer-Reviewed Original ResearchConceptsSite-directed recombinationDNA repairNucleotide excision repair factorsExcision repair factorsSite-specific DNASite-specific recombinationHuman cell-free extractsDonor DNA fragmentsRepair factorsMammalian cellsGenetic manipulationCell-free extractsTarget genesSite-directed mannerReporter geneStrand invasionPlasmid substratesDNA fragmentsDefective geneDonor DNAWatson-Crick base pairingDuplex DNAGenesTarget plasmidDNA