Improving detection of higher-risk or locally advanced disease features in stage I and II renal cell carcinoma.
Miller N, Derweesh I, Liu M, Bradshaw A, Dutt R, Keiner C, Meagher M, Ghali F, Patel D, Wan F, Shiehmorteza M. Improving detection of higher-risk or locally advanced disease features in stage I and II renal cell carcinoma. Journal Of Clinical Oncology 2020, 38: 625-625. DOI: 10.1200/jco.2020.38.6_suppl.625.Peer-Reviewed Original ResearchRenal cell carcinomaT3a renal cell carcinomaPerinephric fat invasionSinus fat invasionTumor edgeFat invasionVenous invasionCell carcinomaTumor necrosisPerirenal fasciaSingle-institution retrospective analysisT2 renal cell carcinomaAdvanced disease featuresPreoperative clinical stageAccuracy of CTPreoperative CT imagesPathological upstagingPerinephric strandingT3a diseaseUpstaged patientsUpstaged tumorsClinical suspicionMultivariable analysisOncologic riskAggressive diseaseDoes pathologic upstaging to PT3A portend a worsened prognosis when compared to non-upstaged PT3A renal cell carcinoma: Analysis of the National Cancer Database.
Patel D, Ghali F, Meagher M, Bradshaw A, Patel S, Keiner C, Miller N, Dutt R, Murphy J, Derweesh I. Does pathologic upstaging to PT3A portend a worsened prognosis when compared to non-upstaged PT3A renal cell carcinoma: Analysis of the National Cancer Database. Journal Of Clinical Oncology 2020, 38: 624-624. DOI: 10.1200/jco.2020.38.6_suppl.624.Peer-Reviewed Original ResearchPT3a renal cell carcinomaRenal cell carcinomaNational Cancer DatabasePartial nephrectomyClinical stageOverall survivalPT3a tumorsCell carcinomaPathological upstagingUpstaged tumorsCancer DatabaseT3a renal cell carcinomaMultivariable Cox proportional hazardsKaplan-Meier survival analysisPre-treatment detectionRisk stratification protocolCharlson Comorbidity IndexImproved overall survivalFinal pathological analysisAJCC staging systemKaplan-Meier analysisSmaller tumor sizeLower clinical stagePositive margin statusCox proportional hazards