ALTERED BIOLOGICAL ACTIVITY ASSOCIATED WITH C-TERMINAL MODIFICATIONS OF IL-7
Görgün G, van der Spek J, Cosenza L, Menevse A, Foss F. ALTERED BIOLOGICAL ACTIVITY ASSOCIATED WITH C-TERMINAL MODIFICATIONS OF IL-7. Cytokine 2002, 20: 17-22. PMID: 12441142, DOI: 10.1006/cyto.2002.1974.Peer-Reviewed Original ResearchConceptsLigand-binding inducesSrc-related kinasesLigand-receptor interactionsAltered biological activityTyrosine phosphorylationC-terminal modificationBiological activityB leukemia cellsJAK3 kinaseHydrophobic residuesGamma subunitsSelective biological activityCarboxyterminal regionAliphatic amino acidsIL-7Amino acidsKinaseIL-7 receptorBinding antagonistsSubunitsIL-7R.Epithelial tissuesGammac subunitsCell functionIL-7RInterleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines
Cosenza L, Gorgun G, Urbano A, Foss F. Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines. Cellular Signalling 2002, 14: 317-325. PMID: 11858939, DOI: 10.1016/s0898-6568(01)00245-5.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsCell LineEpithelial CellsHematopoietic Stem CellsHumansImmunoblottingInterleukin Receptor Common gamma SubunitJanus Kinase 3Lung NeoplasmsNeoplasmsNuclease Protection AssaysProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-fynReceptors, Interleukin-7RNA, MessengerSignal TransductionTissue DistributionTranscription, GeneticTumor Cells, CulturedConceptsIL-7R mRNABrain tumor cell linesIL-7RIL-7RalphaCell linesTumor cell linesInterleukin-7 receptor expressionReceptor-directed therapyNational Cancer Institute tumor panelBreast cancer cell linesReceptor gamma chainLung cancer cellsInterleukin-2 receptor gamma chainHeterodimeric complex consistingS1 nuclease protection assaysCellular differentiation processesEpithelial tumor cellsCancer cell linesNuclease protection assaysS1 nuclease protectionLung cancerSerine residue phosphorylationReceptor expressionNeoplastic cell linesInterleukin-7