2013
Polymorphisms in DNA repair pathway genes, body mass index, and risk of non‐Hodgkin lymphoma
Chen Y, Zheng T, Lan Q, Kim C, Qin Q, Foss F, Chen X, Holford T, Leaderer B, Boyle P, Wang C, Dai M, Liu Z, Ma S, Chanock SJ, Rothman N, Zhang Y. Polymorphisms in DNA repair pathway genes, body mass index, and risk of non‐Hodgkin lymphoma. American Journal Of Hematology 2013, 88: 606-611. PMID: 23619945, PMCID: PMC3902049, DOI: 10.1002/ajh.23463.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBody Mass IndexCase-Control StudiesDNA RepairDNA-Binding ProteinsExodeoxyribonucleasesFemaleGenotypeHumansLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinMiddle AgedPolymorphism, GeneticRecQ HelicasesRisk FactorsUbiquitin-Protein LigasesWerner Syndrome HelicaseX-ray Repair Cross Complementing Protein 1Xeroderma Pigmentosum Group D ProteinConceptsBody mass indexNon-Hodgkin lymphomaDNA repair pathway genesCT/TTMass indexNHL riskPopulation-based case-control studyRisk of NHLDiffuse large B-cell lymphomaGT/TT genotypesLarge B-cell lymphomaAC/CCT-cell lymphomaCase-control studyB-cell lymphomaConnecticut womenTT genotypeGG genotypePathway genesLymphomaCommon genetic variationWomenRiskSignificant interaction
2012
Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non‐Hodgkin lymphoma
Bi X, Zheng T, Lan Q, Xu Z, Chen Y, Zhu G, Foss F, Kim C, Dai M, Zhao P, Holford T, Leaderer B, Boyle P, Deng Q, Chanock SJ, Rothman N, Zhang Y. Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non‐Hodgkin lymphoma. American Journal Of Hematology 2012, 87: 766-769. PMID: 22649007, PMCID: PMC3576861, DOI: 10.1002/ajh.23244.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaAG/AA genotypesHistory of transfusionBlood transfusionB-cell lymphomaGG genotypeAA genotypePopulation-based case-control studyRisk of NHLGenetic polymorphismsT-cell lymphomaCase-control studyDecreased riskNHL overallIL10RA geneConnecticut womenNHL riskTh2 cytokine genesTransfusionLymphomaCytokine genesTNFWomenRiskIL10RAGenetic Polymorphisms in Oxidative Stress Pathway Genes and Modification of BMI and Risk of Non-Hodgkin Lymphoma
Kim C, Zheng T, Lan Q, Chen Y, Foss F, Chen X, Holford T, Leaderer B, Boyle P, Chanock SJ, Rothman N, Zhang Y. Genetic Polymorphisms in Oxidative Stress Pathway Genes and Modification of BMI and Risk of Non-Hodgkin Lymphoma. Cancer Epidemiology Biomarkers & Prevention 2012, 21: 866-868. PMID: 22374993, PMCID: PMC3394153, DOI: 10.1158/1055-9965.epi-12-0010.Peer-Reviewed Original ResearchConceptsRisk of NHLBody mass indexNon-Hodgkin lymphomaOxidative stress pathway genesStress pathway genesStudies of BMIPopulation-based case-control studyOxidative stressPathway single nucleotide polymorphismsOverweight/obeseCase-control studyLarger study populationIncreases oxidative stressFalse discovery rate adjustmentHistologic subtypeMass indexRisk factorsConnecticut womenNHL riskStudy populationUnderweight individualsCommon genetic variationOxidative stress genesGenetic polymorphismsSingle nucleotide polymorphisms
2010
Cytokine polymorphisms in Th1/Th2 pathway genes, body mass index, and risk of non-Hodgkin lymphoma
Chen Y, Zheng T, Lan Q, Foss F, Kim C, Chen X, Dai M, Li Y, Holford T, Leaderer B, Boyle P, Chanock SJ, Rothman N, Zhang Y. Cytokine polymorphisms in Th1/Th2 pathway genes, body mass index, and risk of non-Hodgkin lymphoma. Blood 2010, 117: 585-590. PMID: 20952689, PMCID: PMC3031482, DOI: 10.1182/blood-2010-07-295097.Peer-Reviewed Original ResearchConceptsBody mass indexNon-Hodgkin lymphomaAG/GGB-cell lymphomaMass indexCommon B-cell lymphoma subtypesSmall lymphocytic lymphoma/chronic lymphocytic leukemiaRisk of NHLMarginal zone B-cell lymphomaCT/TT genotypesB-cell lymphoma subtypesT-cell lymphomaCase-control studyCT/TTChronic lymphocytic leukemiaNHL overallConnecticut womenNHL riskLymphocytic leukemiaLymphoma subtypesTh2 cytokine genesFollicular lymphomaTT genotypeSignificant interactionLymphoma