ALTERED BIOLOGICAL ACTIVITY ASSOCIATED WITH C-TERMINAL MODIFICATIONS OF IL-7
Görgün G, van der Spek J, Cosenza L, Menevse A, Foss F. ALTERED BIOLOGICAL ACTIVITY ASSOCIATED WITH C-TERMINAL MODIFICATIONS OF IL-7. Cytokine 2002, 20: 17-22. PMID: 12441142, DOI: 10.1006/cyto.2002.1974.Peer-Reviewed Original ResearchConceptsLigand-binding inducesSrc-related kinasesLigand-receptor interactionsAltered biological activityTyrosine phosphorylationC-terminal modificationBiological activityB leukemia cellsJAK3 kinaseHydrophobic residuesGamma subunitsSelective biological activityCarboxyterminal regionAliphatic amino acidsIL-7Amino acidsKinaseIL-7 receptorBinding antagonistsSubunitsIL-7R.Epithelial tissuesGammac subunitsCell functionIL-7RSTRUCTURE FUNCTION ANALYSIS OF INTERLEUKIN 7: REQUIREMENT FOR AN AROMATIC RING AT POSITION 143 OF HELIX D
vanderSpek JC, Sutherland JA, Gill BM, Gorgun G, Foss FM, Murphy JR. STRUCTURE FUNCTION ANALYSIS OF INTERLEUKIN 7: REQUIREMENT FOR AN AROMATIC RING AT POSITION 143 OF HELIX D. Cytokine 2002, 17: 227-233. PMID: 12027403, DOI: 10.1006/cyto.2002.1004.Peer-Reviewed Original ResearchAnimalsBinding, CompetitiveCell LineDose-Response Relationship, DrugElectrophoresis, Polyacrylamide GelEscherichia coliHistidineHumansInhibitory Concentration 50Interleukin-7MiceMutagenesis, Site-DirectedMutationPhenylalaninePlasmidsProlineProtein BindingProtein Structure, TertiaryReceptors, Interleukin-7Signal TransductionTryptophanTyrosine