2010
Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy
Berger C, Hoffmann K, Vasquez JG, Mane S, Lewis J, Filler R, Lin A, Zhao H, Durazzo T, Baird A, Lin W, Foss F, Christensen I, Girardi M, Tigelaar R, Edelson R. Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy. Blood 2010, 116: 4838-4847. PMID: 20720185, PMCID: PMC3321745, DOI: 10.1182/blood-2009-11-256040.Peer-Reviewed Original ResearchMeSH KeywordsAntigen PresentationCell DifferentiationCell SeparationDendritic CellsFlow CytometryGene ExpressionGraft vs Host DiseaseHumansImmunophenotypingIn Situ HybridizationLymphoma, T-Cell, CutaneousMonocytesOligonucleotide Array Sequence AnalysisPhotopheresisReverse Transcriptase Polymerase Chain ReactionConceptsCutaneous T-cell lymphomaCostimulatory surface moleculesHuman dendritic cellsT-cell lymphomaDC differentiation pathwayAutoreactive disordersTherapeutic DCsDifferentiation pathwayHost diseaseDendritic cellsExtracorporeal photochemotherapyDistinctive molecular signaturesClinical efficacyOrgan rejectionCancer immunotherapyFunctional DCsEndogenous antigensNormal monocytesNormal subjectsClinical successCell differentiation pathwayLevel of expressionDisease statesMonocytesEnhanced expression
2008
Reduced-Intensity and Nonmyeloablative Conditioning Regimens
Foss F, van Besien K. Reduced-Intensity and Nonmyeloablative Conditioning Regimens. Cancer Treatment And Research 2008, 144: 209-232. PMID: 19779868, DOI: 10.1007/978-0-387-78580-6_9.Peer-Reviewed Original Research
2006
The Role of Purine Analogues in Low-Intensity Regimens With Allogeneic Hematopoietic Stem Cell Transplantation
Foss FM. The Role of Purine Analogues in Low-Intensity Regimens With Allogeneic Hematopoietic Stem Cell Transplantation. Seminars In Hematology 2006, 43: s35-s43. PMID: 16549113, DOI: 10.1053/j.seminhematol.2005.12.007.Peer-Reviewed Original ResearchConceptsBone marrow transplantationAllogeneic stem cellsAcute GVHDConditioning regimensExtracorporeal photopheresisDendritic cellsAllogeneic hematopoietic stem cell transplantationLeukemia/lymphoma (GVL) effectT-cell-depleted graftsAllogeneic bone marrow transplantationHematopoietic stem cell transplantationDonor/recipient matchingAlternative stem cell sourceDonor dendritic cellsFull donor engraftmentHost dendritic cellsSevere acute GVHDTransplant-associated morbidityTransplant-associated toxicityMyeloablative conditioning regimensSeverity of GVHDT effector cellsT-cell depletionInduction of immunosuppressionStem cell transplantation
2003
Extracorporeal Photopheresis in the Treatment of Graft-vs-Host Disease
Foss FM. Extracorporeal Photopheresis in the Treatment of Graft-vs-Host Disease. Journal Of Cutaneous Medicine And Surgery 2003, 7: 13-17. DOI: 10.1177/12034754030070s404.Peer-Reviewed Original ResearchAdrenal Cortex HormonesAdultAnimalsBone Marrow TransplantationChildClinical Trials as TopicDendritic CellsDisease Models, AnimalDogsFollow-Up StudiesGraft vs Host DiseaseHumansImmunosuppressive AgentsMicePentostatinPhotopheresisPilot ProjectsQuality of LifeRisk FactorsStem Cell TransplantationTime FactorsTissue DonorsTreatment OutcomeWhole-Body IrradiationPersistence of host dendritic cells after transplantation is associated with graft-versus-host disease
Chan GW, Gorgun G, Miller KB, Foss FM. Persistence of host dendritic cells after transplantation is associated with graft-versus-host disease. Transplantation And Cellular Therapy 2003, 9: 170-176. DOI: 10.1016/s1083-8791(03)70006-8.Peer-Reviewed Original ResearchConceptsReduced-intensity preparative regimenHost dendritic cellsReduced-intensity regimenPreparative regimenTotal body irradiationDendritic cellsAcute GVHDChronic GVHDDC chimerismConventional regimenBody irradiationAllogeneic bone marrow transplantationAllogeneic bone marrow transplantAllogeneic stem cell transplantationExtensive chronic GVHDDevelopment of GVHDStem cell transplantationBone marrow transplantationBone marrow transplantExtracorporeal photophoresisHost diseaseMarrow transplantationSignificant morbidityMarrow transplantCell transplantation
2002
Immunologic mechanisms of extracorporeal photochemotherapy in chronic graft-versus-host disease
Gorgun G, Miller KB, Foss FM. Immunologic mechanisms of extracorporeal photochemotherapy in chronic graft-versus-host disease. Blood 2002, 100: 941-947. PMID: 12130506, DOI: 10.1182/blood-2002-01-0068.Peer-Reviewed Original ResearchConceptsMixed lymphocyte reactionAntigen-presenting dendritic cellsDendritic cellsT cellsChronic graftHost diseaseClinical responseDC populationsActivity of DCsAllogeneic bone marrow transplantationCD4/CD8 ratioMonocytic dendritic cellsAllogeneic T cellsEffector T cellsNatural killer cellsBone marrow transplantationTh2 cytokine profileChronic GVHDCD8 ratioCytokine profileECP therapyImmunologic mechanismsLymphocyte subpopulationsEffector lymphocytesKiller cellsImmunologic mechanisms of antitumor activity
Foss FM. Immunologic mechanisms of antitumor activity. Seminars In Oncology 2002, 29: 5-11. PMID: 12068382, DOI: 10.1053/sonc.2002.33076.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsCytotoxic T lymphocytesEffector cellsCostimulatory moleculesT lymphocytesImmune responseTumor antigensImmune effectorsTumor-specific cytotoxic T lymphocytesTumor cellsMHC complexesEffector cell expansionInadequate immune responseImmune effector cellsHost immune surveillanceAntigen class ICostimulatory adhesion moleculesTumor-associated peptidesT cell receptorOverall immunosuppressionCytokine therapyImmunologic mechanismsAdvanced cancerAntitumor responseTumor escape