Featured Publications
Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw?
Morris MT, Alder KD, Moushey A, Munger AM, Milligan K, Toombs C, Conway D, Lee I, Chen F, Tommasini SM, Lee FY. Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw? Clinical Biomechanics 2022, 92: 105565. PMID: 34999389, DOI: 10.1016/j.clinbiomech.2021.105565.Peer-Reviewed Original ResearchConceptsCyclic loadingEnergy absorptionFinite element analysisHigh energy absorptionElement analysisBone defectsComposite boneStress relaxationSkeletal reinforcementReinforcement techniquesCement augmentation proceduresCementLoadingBone cement augmentationNumerous clinical advantagesBiomechanical testingPeriacetabular defectsFracture locationOsteolytic metastasesIntraarticular fracturesJoint preservationAcetabular augmentationCombination of screwsBiomechanical restorationFixation groupSmoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains
Hao Z, Li J, Li B, Alder KD, Cahill SV, Munger AM, Lee I, Kwon H, Back J, Xu S, Kang M, Lee FY. Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains. Journal Of Bone And Mineral Research 2020, 36: 186-198. PMID: 32866293, PMCID: PMC9057220, DOI: 10.1002/jbmr.4175.Peer-Reviewed Original ResearchConceptsCigarette smoke exposureCigarette smokingFracture healingSmoke exposureMurine modelMolecular alterationsBALB/cJ miceBiomechanical testingPro-inflammatory mediatorsCytokine/chemokine analysisImpaired fracture healingMultiplex cytokine/chemokine analysisInitial inflammatory responseFracture healing capacityBALB/cJProgenitor cell activitySmoking miceTransverse femoral osteotomyFemoral osteotomyImmune cellsChemokine analysisInflammatory responseFracture hematomaHigh riskMurine strains
2015
Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones
Vorys GC, Bai H, Chandhanayingyong C, Lee CH, Compton JT, Caldwell JM, Gardner TR, Mao JJ, Lee FY. Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones. Clinical Biomechanics 2015, 30: 1114-1118. PMID: 26386637, PMCID: PMC9004608, DOI: 10.1016/j.clinbiomech.2015.08.016.Peer-Reviewed Original ResearchConceptsTorsional stiffnessHydroxyapatite composite scaffoldsCyclic torsional testsNon-locking fixationMassive segmental defectsTissue engineering strategiesLarge segmental bone defectsComposite scaffoldsLoading cyclesTorque controlSynthetic bone graftAxial stiffnessAngular rotationAxial compressionTorsional testsNon-destructive mannerGeometry representativeOptimal screw fixationSegmental bone defectsSuch scaffoldsTorque levelsStiffnessBiomechanical testingHuman tibiaEngineering strategies