2014
A Review of Osteocyte Function and the Emerging Importance of Sclerostin
Compton JT, Lee FY. A Review of Osteocyte Function and the Emerging Importance of Sclerostin. Journal Of Bone And Joint Surgery 2014, 96: 1659-1668. PMID: 25274791, PMCID: PMC4179450, DOI: 10.2106/jbjs.m.01096.Peer-Reviewed Original ResearchConceptsBone massPhase III clinical trialsMetastatic bone diseaseOsteoporosis-related fracturesBone mineral densityBone cellsExtensive dendritic networkNormal physiologic stateSclerostin actsParathyroid hormoneInflammatory moleculesBone metabolismClinical trialsMineral densityProstaglandin E2Bone diseaseSystemic circulationOrthopedic conditionsProtein sclerostinOsseous integrationSclerostinBone cell populationsPhysiologic stateCell populationsOsteocyte function
2012
MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions
Chandhanayingyong C, Kim Y, Staples JR, Hahn C, Lee FY. MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions. Sarcoma 2012, 2012: 404810. PMID: 22577336, PMCID: PMC3345255, DOI: 10.1155/2012/404810.Peer-Reviewed Original ResearchBone sarcomasClinical trialsEwing's sarcomaLimb salvage surgeryCurrent therapeutic modalitiesRecent clinical trialsMAPK/ERK inhibitorsPromising therapeutic targetHigh-grade chondrosarcomaCytotoxic chemotherapeutic drugsMAPK/ERK signalingSalvage surgeryTherapy regimensClinical benefitMetastatic osteosarcomaInflammatory responseMAPK/ERKClinical dataLocal invasivenessTherapeutic modalitiesCurrent chemotherapyTherapeutic conceptsTherapeutic implicationsTherapeutic targetSarcoma