2012
Modern Interpretation of Giant Cell Tumor of Bone: Predominantly Osteoclastogenic Stromal Tumor
Kim Y, Nizami S, Goto H, Lee FY. Modern Interpretation of Giant Cell Tumor of Bone: Predominantly Osteoclastogenic Stromal Tumor. Clinics In Orthopedic Surgery 2012, 4: 107-116. PMID: 22662295, PMCID: PMC3360182, DOI: 10.4055/cios.2012.4.2.107.Peer-Reviewed Original ResearchConceptsGiant cell tumorStromal cell-derived factor-1Tumor necrosis factorCell tumorsBone destructionNuclear factor kappa-B ligandCell-derived factor-1Stromal cell tumorsPro-osteoclastogenic cytokinesGCT treatmentAdjuvant therapySurgical excisionStromal tumorsTumor comprisingInflammatory cytokinesChemoattractant proteinNecrosis factorParacrine loopExcessive osteoclastogenesisReceptor activatorOrthopaedic surgeonsOsteoclast precursorsOsteoclastic cellsMesenchymal originTumors
2008
What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?
Tuan RS, Lee FY, T Konttinen Y, Wilkinson JM, Smith RL. What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles? Journal Of The American Academy Of Orthopaedic Surgeons 2008, 16 Suppl 1: s42-8. PMID: 18612013, PMCID: PMC2714366, DOI: 10.5435/00124635-200800001-00010.Peer-Reviewed Original ResearchMeSH KeywordsBasic Helix-Loop-Helix Transcription FactorsBiocompatible MaterialsBone ResorptionDinoprostoneEndothelial CellsFibroblastsForeign-Body ReactionHumansInterleukin-1Interleukin-6Interleukin-8Joint ProsthesisMacrophage Colony-Stimulating FactorOsteoclastsOsteogenesisProsthesis FailureRANK LigandStem CellsT-LymphocytesTumor Necrosis Factor-alphaConceptsBone lossTNF-alphaIL-1Inflammatory bone lossPro-osteoclastogenic cytokinesGene functionHost inflammatory responsePeriprosthetic bone lossBone marrow-derived mesenchymal stem cellsMarrow-derived mesenchymal stem cellsGenetic variationBasic science dataMolecular mechanismsMesenchymal stem cellsMechanism of actionPeriprosthetic inflammationIL-6IL-8M-SCFInflammatory responseT cellsStem cellsAltered susceptibilityBiologic effectsOsteoprogenitor cells