Featured Publications
Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw?
Morris MT, Alder KD, Moushey A, Munger AM, Milligan K, Toombs C, Conway D, Lee I, Chen F, Tommasini SM, Lee FY. Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw? Clinical Biomechanics 2022, 92: 105565. PMID: 34999389, DOI: 10.1016/j.clinbiomech.2021.105565.Peer-Reviewed Original ResearchMeSH KeywordsAcetabulumBiomechanical PhenomenaBone CementsBone ScrewsFracture Fixation, InternalHumansNeoplasmsConceptsCyclic loadingEnergy absorptionFinite element analysisHigh energy absorptionElement analysisBone defectsComposite boneStress relaxationSkeletal reinforcementReinforcement techniquesCement augmentation proceduresCementLoadingBone cement augmentationNumerous clinical advantagesBiomechanical testingPeriacetabular defectsFracture locationOsteolytic metastasesIntraarticular fracturesJoint preservationAcetabular augmentationCombination of screwsBiomechanical restorationFixation group
2015
Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones
Vorys GC, Bai H, Chandhanayingyong C, Lee CH, Compton JT, Caldwell JM, Gardner TR, Mao JJ, Lee FY. Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones. Clinical Biomechanics 2015, 30: 1114-1118. PMID: 26386637, PMCID: PMC9004608, DOI: 10.1016/j.clinbiomech.2015.08.016.Peer-Reviewed Original ResearchConceptsTorsional stiffnessHydroxyapatite composite scaffoldsCyclic torsional testsNon-locking fixationMassive segmental defectsTissue engineering strategiesLarge segmental bone defectsComposite scaffoldsLoading cyclesTorque controlSynthetic bone graftAxial stiffnessAngular rotationAxial compressionTorsional testsNon-destructive mannerGeometry representativeOptimal screw fixationSegmental bone defectsSuch scaffoldsTorque levelsStiffnessBiomechanical testingHuman tibiaEngineering strategies
2013
Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study
Amorosa L, Lee C, Aydemir, Nizami S, Hsu A, Patel N, Gardner T, Navalgund A, Kim DG, Park S, Mao J, Lee F. Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study. International Journal Of Nanomedicine 2013, Volume 8: 1637-1643. PMID: 23637532, PMCID: PMC3639117, DOI: 10.2147/ijn.s42855.Peer-Reviewed Original ResearchConceptsAddition of hMSCsPolymer-based scaffoldsLoad-bearing characteristicsPhysiologic cyclic loadingPhase angleCritical-sized segmental defectsScaffold alone groupViscous stiffnessCyclic loadingMechanical propertiesFemoral defect modelSized segmental defectsRat femoral defect modelHuman mesenchymal stem cellsMechanical simulationsScaffold groupDifferent biomechanical characteristicsEnhanced bone formationHigh phase anglesDefect modelBiomechanical characteristicsExperimental studyHost boneStiffnessDefect repair
2009
Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model
Cadet ER, Vorys GC, Rahman R, Park S, Gardner TR, Lee FY, Levine WN, Bigliani LU, Ahmad CS. Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model. Journal Of Orthopaedic Research® 2009, 28: 308-314. PMID: 19743506, DOI: 10.1002/jor.20972.Peer-Reviewed Original ResearchConceptsBone densityRotator cuff footprintOVX groupRat modelSupraspinatus tendonCuff footprintQuantitative micro-computed tomographyMonths of ageBisphosphonate treatmentOVX ratsBilateral ovariectomyProximal humerusDawley ratsAdditional ratsOVXRatsTendonOvariectomyMicro-computed tomographyTreatmentGroupBisphosphonatesSpragueHumerusMonths
2006
Mechanical Loading Differentially Regulates Membrane‐Bound and Soluble RANKL Availability in MC3T3‐E1 Cells
KIM DW, LEE H, KARMIN JA, LEE E, CHANG S, TOLCHIN B, LIN S, CHO SK, KWON A, AHN JM, LEE F. Mechanical Loading Differentially Regulates Membrane‐Bound and Soluble RANKL Availability in MC3T3‐E1 Cells. Annals Of The New York Academy Of Sciences 2006, 1068: 568-572. PMID: 16831954, DOI: 10.1196/annals.1346.054.Peer-Reviewed Original Research
2001
Coronal Split Fracture of the Proximal Tibia Epiphysis Through a Partially Closed Physis: A New Fracture Pattern
Patari S, Lee F, Behrens F. Coronal Split Fracture of the Proximal Tibia Epiphysis Through a Partially Closed Physis: A New Fracture Pattern. Journal Of Pediatric Orthopaedics 2001, 21: 451. PMID: 11433155, DOI: 10.1097/01241398-200107000-00007.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsAdolescentBicyclingBiomechanical PhenomenaEpiphysesExternal FixatorsFollow-Up StudiesFracture Fixation, InternalFracture HealingFractures, ComminutedGaitHumansMaleRange of Motion, ArticularRisk FactorsTibial FracturesTomography, X-Ray ComputedTreatment OutcomeWeight-BearingConceptsCoronal split fractureProximal tibial epiphysisTibial epiphysisSplit fractureDefinitive operative fixationProximal tibia epiphysisNew fracture patternClinical unionUncommon injuryOperative fixationEpiphyseal fracturesPlain radiographyTibial plateauTibia epiphysisEpiphysisFracture patternsFracturesPatientsThree-dimensional reconstructionInjuryPhysis
1998
Micromechanical Properties of Epiphyseal Trabecular Bone and Primary Spongiosa Around the Physis: An In Situ Nanoindentation Study
Lee F, Rho J, Harten R, Parsons J, Behrens F. Micromechanical Properties of Epiphyseal Trabecular Bone and Primary Spongiosa Around the Physis: An In Situ Nanoindentation Study. Journal Of Pediatric Orthopaedics 1998, 18: 582-585. PMID: 9746404, DOI: 10.1097/00004694-199809000-00004.Peer-Reviewed Original Research
1997
Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing
Harten R, Lee F, Zimmerman M, Hurowitz E, Arakal R, Behrens F. Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing. Journal Of Orthopaedic Research® 1997, 15: 570-576. PMID: 9379267, DOI: 10.1002/jor.1100150413.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic Impedance TestsAnimalsBiomechanical PhenomenaBony CallusFemoral FracturesFracture HealingMaleMicroscopyRatsRats, Sprague-DawleyTime FactorsConceptsScanning acoustic microscopeMechanical propertiesAcoustic microscopyAcoustic microscopeMaterial propertiesAcoustic impedance mapsConventional testing methodsAcoustic propertiesImpedanceSecondary bone healingImpedance mapsTesting methodsPropertiesAccurate determinationBone healingPopular choiceFracturesLinear relationshipFracture healingDevicesPolymethylmethacrylateMicroscopeMean impedanceMaterials