Featured Publications
Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw?
Morris MT, Alder KD, Moushey A, Munger AM, Milligan K, Toombs C, Conway D, Lee I, Chen F, Tommasini SM, Lee FY. Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw? Clinical Biomechanics 2022, 92: 105565. PMID: 34999389, DOI: 10.1016/j.clinbiomech.2021.105565.Peer-Reviewed Original ResearchMeSH KeywordsAcetabulumBiomechanical PhenomenaBone CementsBone ScrewsFracture Fixation, InternalHumansNeoplasmsConceptsCyclic loadingEnergy absorptionFinite element analysisHigh energy absorptionElement analysisBone defectsComposite boneStress relaxationSkeletal reinforcementReinforcement techniquesCement augmentation proceduresCementLoadingBone cement augmentationNumerous clinical advantagesBiomechanical testingPeriacetabular defectsFracture locationOsteolytic metastasesIntraarticular fracturesJoint preservationAcetabular augmentationCombination of screwsBiomechanical restorationFixation groupEmerging Minimally Invasive Percutaneous Procedures for Periacetabular Osteolytic Metastases
Ibe I, Dussik C, Callan A, Barr J, Lee F. Emerging Minimally Invasive Percutaneous Procedures for Periacetabular Osteolytic Metastases. Journal Of Bone And Joint Surgery 2023, 105: 479-489. PMID: 36701566, DOI: 10.2106/jbjs.22.00694.Peer-Reviewed Original ResearchConceptsInvasive percutaneous proceduresOsteolytic metastasesInvasive proceduresPercutaneous proceduresCancer ablationOsteolytic skeletal metastasesOpen surgical managementPercutaneous screw fixationSystemic cancer therapyOpen surgical proceduresRestoration of ambulationComplex open surgical proceduresPeriacetabular osteolytic lesionsBalloon osteoplastyAmbulatory functionTotal hip reconstructionBlood lossOsteolytic lesionsSkeletal metastasesSurgical managementInterventional oncologistsInternal fixationSurgical proceduresInvasive techniquesScrew fixationAblation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases.
Toombs C, Conway D, Munger AM, Alder KD, Latich I, Lee FY. Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases. Instructional Course Lectures 2021, 70: 503-514. PMID: 33438931.Peer-Reviewed Original ResearchMeSH KeywordsBone CementsBone NeoplasmsCementoplastyFracture Fixation, InternalHumansOsteolysisTreatment OutcomeConceptsInternal fixationLocal cancer controlBalloon osteoplastySurgical stabilizationCancer controlConventional open surgical proceduresLocal cancer progressionProgressive bone destructionFirst-line treatmentPercutaneous treatment optionsAmbulatory surgery settingProgressive bone lossSurgical reconstructive proceduresEarly clinical resultsImage-guided ablationNew effective therapiesOpen surgical proceduresInvasive surgical interventionOptimal internal fixationOsteolytic metastatic diseasePolymethyl methacrylate cementUncontrolled painMetastatic diseaseBone destructionOsteolytic metastases
2020
Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones
Lee FY, Latich I, Toombs C, Mungur A, Conway D, Alder K, Ibe I, Lindskog D, Friedlaender G. Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones. Journal Of Vascular And Interventional Radiology 2020, 31: 649-658.e1. PMID: 32139256, DOI: 10.1016/j.jvir.2019.11.029.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAdultAgedAged, 80 and overBone CementsBone NeoplasmsBone RemodelingBone ScrewsCalcaneusCementoplastyFemaleFemoral NeoplasmsFemurFracture Fixation, InternalHumansMaleMiddle AgedOsteolysisPelvic BonesPostoperative ComplicationsProspective StudiesRecovery of FunctionTibiaTime FactorsTreatment OutcomeWeight-BearingConceptsOsteolytic lesionsInternal fixationVisual analog scale pain scoreMusculoskeletal Tumor Society scoreProspective clinical cohort studyFunctional ambulation scoreOsteolytic skeletal lesionsPainful osteolytic lesionsScale pain scoresClinical cohort studyInvasive percutaneous approachWeight-bearing boneInternal fixation screwsBalloon osteoplastyPain scoresCohort studyProphylactic stabilizationSevere painSociety ScoreConsecutive patientsSurgical treatmentEarly outcomesTreatment optionsPercutaneous approachFunctional improvement
2019
Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone
Greenberg DD, Lee FY. Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone. American Journal Of Clinical Oncology 2019, 42: 231-237. PMID: 30811352, DOI: 10.1097/coc.0000000000000504.Peer-Reviewed Original ResearchConceptsGiant cell tumorAdjuvant therapyLocal adjuvant therapySystemic side effectsAvascular necrosisCell tumorsSide effectsMusculoskeletal Tumor Society scoreOsteoclast-like giant cellsAggressive bone resorptionTherapeutic Level IVHigh-speed burringLocal recurrence rateAtypical femur fracturesLevel of evidenceTraditional adjuvant therapyBone cementAtypical fracturesSystemic bisphosphonatesPulmonary metastasesSociety ScoreCurettage proceduresRecurrence rateFemur fracturesPolymethylmethacrylate bone cement