2017
Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice
Mirza F, Lorenzo J, Drissi H, Lee FY, Soung DY. Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice. The Journal Of Nutritional Biochemistry 2017, 52: 54-61. PMID: 29149648, DOI: 10.1016/j.jnutbio.2017.10.002.Peer-Reviewed Original ResearchConceptsTumor necrosis factorTransgenic miceRheumatoid arthritisNuclear factor-kappa B activationDP dietBone-preserving propertiesReduction of synovitisPresence of TNFFour-week treatmentOnset of arthritisResistant acid phosphatase-positive cellsAcid phosphatase-positive cellsDestruction of jointsHuman synovial fibroblastsTNF-transgenic miceHuman tumor necrosis factorKappa B activationActivated T cellsFormation of osteoclastsMouse bone marrow macrophagesBone marrow macrophagesArticular cartilagePostmenopausal womenInflammatory arthritisBone erosion
2015
Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response
Tascau L, Gardner T, Anan H, Yongpravat C, Cardozo CP, Bauman WA, Lee FY, Oh DS, Tawfeek HA. Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response. Endocrinology 2015, 157: 112-126. PMID: 26488807, DOI: 10.1210/en.2015-1614.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsBone DensityCells, CulturedEnergy MetabolismEnzyme ActivationFemaleFemurLumbar VertebraeMaleMice, Inbred C57BLMice, TransgenicOsteoblastsOsteocytesOsteogenesisPoint MutationPromoter Regions, GeneticSex CharacteristicsUp-RegulationX-Ray MicrotomographyConceptsBone anabolic responseOb miceMature osteoblastsPKA activationHigher basal PKA activityControl miceAnabolic responseProtein kinase ASerum bone turnover markersBone volume/total volumeBone turnover markersBasal PKA activityFemur cortical thicknessTotal tissue areaActive PKAKinase AConstitutive activationPKA activityTurnover markersBone lossAnabolic drugsStructure model indexOsteoclast numberFemale miceBone mass
2012
Efficient differentiation of human iPSC‐derived mesenchymal stem cells to chondroprogenitor cells
Guzzo RM, Gibson J, Xu R, Lee FY, Drissi H. Efficient differentiation of human iPSC‐derived mesenchymal stem cells to chondroprogenitor cells. Journal Of Cellular Biochemistry 2012, 114: 480-490. PMID: 22961870, DOI: 10.1002/jcb.24388.Peer-Reviewed Original Research
2011
Interleukin‐1β stimulates stromal‐derived factor‐1α expression in human subacromial bursa
Blaine TA, Cote MA, Proto A, Mulcahey M, Lee FY, Bigliani LU. Interleukin‐1β stimulates stromal‐derived factor‐1α expression in human subacromial bursa. Journal Of Orthopaedic Research® 2011, 29: 1695-1699. PMID: 21484857, DOI: 10.1002/jor.21416.Peer-Reviewed Original ResearchConceptsHuman subacromial bursaIL-1βIL-6SDF-1α expressionRotator cuff diseaseSubacromial bursaSubacromial bursitisSDF-1α productionSDF-1αCuff diseaseSDF-1α mRNA expressionBursal cellsInterleukin IL-1βSubacromial bursal tissueDose-dependent increaseFactor-1α expressionAnti-human antibodiesSupernatants of cellsRheumatoid controlsLocal cytokinesInflammatory cellsShoulder surgeryInterleukin-1βInflammatory responseIL-1
2006
Stromal cell‐derived factor 1 (SDF‐1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti‐inflammatory agents
Kim Y, Bigliani LU, Fujisawa M, Murakami K, Chang S, Lee H, Lee FY, Blaine TA. Stromal cell‐derived factor 1 (SDF‐1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti‐inflammatory agents. Journal Of Orthopaedic Research® 2006, 24: 1756-1764. PMID: 16779827, DOI: 10.1002/jor.20197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalBursa, SynovialBursitisCells, CulturedChemokine CXCL12Chemokines, CXCCyclooxygenase 2 InhibitorsDexamethasoneDown-RegulationEnzyme-Linked Immunosorbent AssayHumansIn Vitro TechniquesMiddle AgedOligonucleotide Array Sequence AnalysisReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRotator CuffTendinopathyConceptsReal-time reverse transcription-polymerase chain reactionSDF-1 proteinEnzyme-linked immunosorbent assayCOX-2 inhibitorsStromal cell-derived factor-1Cell-derived factor-1SDF-1 expressionSubacromial bursaSDF-1Subacromial bursitisReal-time RT-PCRBursal cellsBursal tissueNormal bone marrow stromal cellsNonsteroidal anti-inflammatory agentsSDF-1 expression levelsAnti-inflammatory medicationsUse of steroidsAnti-inflammatory agentsFactor 1Reverse transcription-polymerase chain reactionSubacromial bursal tissueRotator cuff diseaseTranscription-polymerase chain reactionSubacromial bursa tissue