2019
Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma
Klemen ND, Wang M, Feingold PL, Cooper K, Pavri SN, Han D, Detterbeck FC, Boffa DJ, Khan SA, Olino K, Clune J, Ariyan S, Salem RR, Weiss SA, Kluger HM, Sznol M, Cha C. Patterns of failure after immunotherapy with checkpoint inhibitors predict durable progression-free survival after local therapy for metastatic melanoma. Journal For ImmunoTherapy Of Cancer 2019, 7: 196. PMID: 31340861, PMCID: PMC6657062, DOI: 10.1186/s40425-019-0672-3.Peer-Reviewed Original ResearchConceptsThree-year progression-free survivalProgression-free survivalDisease-specific survivalFive-year disease-specific survivalPatterns of failureDurable progression-free survivalLocal therapyStereotactic body radiotherapyMetastatic melanomaNew metastasesPatient selectionIndependent radiological reviewOngoing complete responseResultsFour hundred twentyEvidence of diseaseCNS metastasisCPI treatmentImmunotherapy failureCheckpoint inhibitorsMost patientsProgressive diseaseRadiological reviewComplete responsePD-1PD-L1
2018
Incorporating Coexisting Chronic Illness into Decisions about Patient Selection for Lung Cancer Screening. An Official American Thoracic Society Research Statement
Rivera MP, Tanner NT, Silvestri GA, Detterbeck FC, Tammemägi MC, Young RP, Slatore CG, Caverly TJ, Boyd CM, Braithwaite D, Fathi JT, Gould MK, Iaccarino JM, Malkoski SP, Mazzone PJ, Tanoue LT, Schoenborn NL, Zulueta JJ, Wiener RS. Incorporating Coexisting Chronic Illness into Decisions about Patient Selection for Lung Cancer Screening. An Official American Thoracic Society Research Statement. American Journal Of Respiratory And Critical Care Medicine 2018, 198: e3-e13. PMID: 30004250, DOI: 10.1164/rccm.201805-0986st.Peer-Reviewed Original ResearchConceptsLung cancer screeningRisk of deathPatient selectionChronic illnessCancer screeningLung cancerOfficial American Thoracic Society Research StatementHarms of LCSImplementation of LCSScreen-detected lung cancersChronic obstructive pulmonary diseaseRisk of comorbiditiesObstructive pulmonary diseaseEffect of comorbidityLung cancer deathsTreatment-related harmsLung cancer riskBalance of benefitsPulmonary diseaseCancer deathBaseline riskCancer riskComorbiditiesHealthy individualsInternational cliniciansRobotic-Assisted Lobectomies in the National Cancer Database
Arnold BN, Thomas DC, Narayan R, Blasberg JD, Detterbeck FC, Boffa DJ, Kim AW. Robotic-Assisted Lobectomies in the National Cancer Database. Journal Of The American College Of Surgeons 2018, 226: 1052-1062.e15. PMID: 29574177, DOI: 10.1016/j.jamcollsurg.2018.03.023.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseRobotic lobectomyLung cancerCancer DatabaseOutcomes of patientsPropensity-matched analysisThoracoscopic surgery lobectomyExperienced hospitalsOverall conversion ratePerioperative morbidityPrimary outcomePatient selectionAttendant sequelaeOpen procedureLobectomyAssisted LobectomyHigh mortalityHospitalPatientsMortalityIndividual hospitalsRate of conversionSignificant differencesYears of experienceOutcomes
2014
Experience With Thoracoscopic Pneumonectomies at a Single Institution
Kim AW, Fonseca AL, Boffa DJ, Detterbeck FC. Experience With Thoracoscopic Pneumonectomies at a Single Institution. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 82-86. PMID: 24755537, DOI: 10.1097/imi.0000000000000058.Peer-Reviewed Original ResearchConceptsVideo-assisted thoracoscopic pneumonectomyThoracoscopic pneumonectomyLung cancerExperienced thoracoscopic surgeonsMetastatic esophageal cancerPrimary lung cancerSingle institution experienceDistant disease recurrenceMultidisciplinary tumor boardKaplan-Meier survivalCompletion pneumonectomyLesser resectionsR0 resectionClinical stagingDisease recurrencePathologic stagingPatient selectionSleeve resectionAtrial fibrillationBronchopleural fistulaClinical parametersComplication profileMedian lengthPreoperative selectionSingle institution
2010
Imaging Requirements in the Practice of Pulmonary Metastasectomy
Detterbeck FC, Grodzki T, Gleeson F, Robert JH. Imaging Requirements in the Practice of Pulmonary Metastasectomy. Journal Of Thoracic Oncology 2010, 5: s134-s139. PMID: 20502248, DOI: 10.1097/jto.0b013e3181dcf64d.Peer-Reviewed Original ResearchConceptsHelical CT scansPulmonary metastasectomyCT scanThin-section scanningBetter patient selectionPrimary imaging modalityPositron emission tomographyPulmonary metastasesFurther metastasesMetastatic sitesPatient selectionSurveillance imagingPeriod of observationEmission tomographyMetastasisImaging modalitiesMetastasectomyReconstruction thicknessPatientsTomographyScansOptimal intervalFollowPalpationWeeks