2009
Chapter 19 The Syndrome of Hypertension and Hyperkalemia (Pseudohypoaldosteronism Type II) WNK Kinases Regulate the Balance Between Renal Salt Reabsorption and Potassium Secretion
Kahle K, Wilson F, Lifton R. Chapter 19 The Syndrome of Hypertension and Hyperkalemia (Pseudohypoaldosteronism Type II) WNK Kinases Regulate the Balance Between Renal Salt Reabsorption and Potassium Secretion. 2009, 313-329. DOI: 10.1016/b978-0-12-449851-8.00019-x.ChaptersRenal potassium secretionLumen-negative potentialPotassium secretionPseudohypoaldosteronism type IINa-Cl cotransporterSalt reabsorptionDistal nephron potassium secretionPotassium channelsRenal outer medullary potassium channelENaC activitySyndrome of hypertensionPotential targetElectrogenic sodium reabsorptionPotassium channel ROMKDistal proton secretionRenal salt reabsorptionBK potassium channelsEpithelial sodium channelMolecular genetic discoveriesSodium reabsorptionWNK kinasesProfound hyperkalemiaImpaired productionMarked impairmentChannel ROMK
2001
Human Hypertension Caused by Mutations in WNK Kinases
Wilson F, Disse-Nicodème S, Choate K, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford D, Lipkin G, Achard J, Feely M, Dussol B, Berland Y, Unwin R, Mayan H, Simon D, Farfel Z, Jeunemaitre X, Lifton R. Human Hypertension Caused by Mutations in WNK Kinases. Science 2001, 293: 1107-1112. PMID: 11498583, DOI: 10.1126/science.1062844.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceChromosome MappingChromosomes, Human, Pair 12Chromosomes, Human, Pair 17CytoplasmFemaleGene Expression Regulation, EnzymologicGenetic LinkageHumansHypertensionIntercellular JunctionsIntracellular Signaling Peptides and ProteinsIntronsKidney Tubules, CollectingKidney Tubules, DistalMaleMembrane ProteinsMicroscopy, FluorescenceMinor Histocompatibility AntigensMolecular Sequence DataMutationMutation, MissensePedigreePhosphoproteinsProtein Serine-Threonine KinasesPseudohypoaldosteronismSequence DeletionSignal TransductionWNK Lysine-Deficient Protein Kinase 1Zonula Occludens-1 ProteinConceptsMajor public health problemPublic health problemRenal salt reabsorptionAntihypertensive drugsHuman hypertensionUnknown causeDistal nephronKidney segmentsPseudohypoaldosteronism type IIHealth problemsSalt reabsorptionHypertensionWNK1 expressionNew targetsWNK kinasesTight junctionsType IISerine-threonine kinaseIntronic deletionWNK4WNK familyMutationsWNK1KinaseExcretion