2009
Chapter 19 The Syndrome of Hypertension and Hyperkalemia (Pseudohypoaldosteronism Type II) WNK Kinases Regulate the Balance Between Renal Salt Reabsorption and Potassium Secretion
Kahle K, Wilson F, Lifton R. Chapter 19 The Syndrome of Hypertension and Hyperkalemia (Pseudohypoaldosteronism Type II) WNK Kinases Regulate the Balance Between Renal Salt Reabsorption and Potassium Secretion. 2009, 313-329. DOI: 10.1016/b978-0-12-449851-8.00019-x.ChaptersRenal potassium secretionLumen-negative potentialPotassium secretionPseudohypoaldosteronism type IINa-Cl cotransporterSalt reabsorptionDistal nephron potassium secretionPotassium channelsRenal outer medullary potassium channelENaC activitySyndrome of hypertensionPotential targetElectrogenic sodium reabsorptionPotassium channel ROMKDistal proton secretionRenal salt reabsorptionBK potassium channelsEpithelial sodium channelMolecular genetic discoveriesSodium reabsorptionWNK kinasesProfound hyperkalemiaImpaired productionMarked impairmentChannel ROMK
2005
Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch
Kahle KT, Wilson FH, Lifton RP. Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch. Trends In Endocrinology And Metabolism 2005, 16: 98-103. PMID: 15808806, DOI: 10.1016/j.tem.2005.02.012.Peer-Reviewed Original ResearchConceptsWNK kinasesSerine-threonine kinaseNovel molecular switchSubstitution of cysteinePhysiological regulatory pathwaysRecent physiological workMolecular genetic studiesCatalytic domainSubdomain IIRegulatory pathwaysIon flux pathwaysMolecular switchWNK4 kinaseKinasePhysiological workBasolateral membranePathwayIon transport pathwaysTransport pathwaysWNK4Electrolyte homeostasisProminent roleSyndrome of hypertensionWNK1Key component