2010
Role of Novel Biomarkers in Chronic Kidney Disease: Renalase
Desir G. Role of Novel Biomarkers in Chronic Kidney Disease: Renalase. 2010, 309-316. DOI: 10.1007/978-88-470-1463-3_24.Peer-Reviewed Original ResearchChronic kidney diseaseBlood pressureKidney diseaseCardiac functionRenalase knockout mouseAcute kidney injurySevere cardiovascular complicationsCardiovascular complicationsKidney injuryEssential hypertensionCardiac injuryMyocardial injuryEarly biomarkersRenalase geneNovel biomarkersKnockout miceTherapeutic utilityRenalaseInjuryProtein expressionSingle nucleotide polymorphismsPreliminary dataDiseaseModest increaseBiomarkers
2009
Regulation of blood pressure and cardiovascular function by renalase
Desir GV. Regulation of blood pressure and cardiovascular function by renalase. Kidney International 2009, 76: 366-370. PMID: 19471322, DOI: 10.1038/ki.2009.169.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseGlomerular filtration rateBlood pressureKidney diseasePlasma catecholaminesCardiovascular functionKnockout miceEnd-stage kidney diseaseRenalase knockout mouseSingle nucleotide polymorphismsRenalase levelsCardiovascular riskEssential hypertensionFiltration rateCardiac functionCardiac ischemiaRenalase geneSignificant fallAnimal modelsRenalaseCatecholaminesHypertensionPatientsFold stimulationAbnormalities
2008
Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease
Desir GV. Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. Current Opinion In Nephrology & Hypertension 2008, 17: 181-185. PMID: 18277152, DOI: 10.1097/mnh.0b013e3282f521ba.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseBlood pressureAnimal modelsCardiac functionEnd-stage renal diseaseRegulation of renalaseSalt-dependent hypertensionDevelopment of hypertensionSystolic blood pressurePlasma renalaseRenalase deficiencyCatecholamine administrationSympathetic toneRenal diseaseKidney functionSubtotal nephrectomyPlasma catecholaminesCardiovascular diseaseHypertensionLower plasmaRenalaseCatecholaminesDiseaseAbnormalities
2007
Renalase, a new renal hormone: its role in health and disease
Xu J, Desir GV. Renalase, a new renal hormone: its role in health and disease. Current Opinion In Nephrology & Hypertension 2007, 16: 373-378. PMID: 17565281, DOI: 10.1097/mnh.0b013e3281bd8877.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseEnd-stage renal diseaseKidney diseaseBlood pressureRenal hormoneRenal diseaseSalt-sensitive Dahl ratsExaggerated blood pressure responseBaseline blood pressureBlood pressure responseSympathetic nervous systemImportant therapeutic modalityRenalase deficiencyCardiovascular riskDahl ratsEssential hypertensionPlasma levelsCardiac functionRecombinant renalaseCardiovascular functionCardiovascular diseaseTherapeutic modalitiesHeart rateRenalase geneAdrenergic stressRenalase is a novel renal hormone that regulates cardiovascular function
Desir GV. Renalase is a novel renal hormone that regulates cardiovascular function. International Journal Of Cardiology Cardiovascular Risk And Prevention 2007, 1: 99-103. PMID: 20409839, DOI: 10.1016/j.jash.2006.12.001.Peer-Reviewed Original ResearchChronic kidney diseaseRenal hormoneBlood pressureKidney diseaseBlood levelsFlavin adenine dinucleotide-dependent amine oxidaseEnd-stage renal diseaseRenal replacement therapySystemic blood pressurePeripheral vascular toneCardiovascular morbidityCardiovascular outcomesSympathetic toneRenal diseaseCatecholamine levelsReplacement therapyVascular tonePatient populationCardiac functionDiseased kidneysCardiovascular functionCardiac contractilityHealthy subjectsHeart rateCompensatory increase
2005
Kidney and Blood Pressure—The Story Unfolds Renalase Is a Novel, Soluble Monoamine Oxidase That Regulates Cardiac Function and Blood Pressure. J Clin Invest
J X, G L, P W, H V, X Y, Y L, Y W, A P, S C, GV D. Kidney and Blood Pressure—The Story Unfolds Renalase Is a Novel, Soluble Monoamine Oxidase That Regulates Cardiac Function and Blood Pressure. J Clin Invest. Journal Of The American Society Of Nephrology 2005, 16: 2521-2527. DOI: 10.1681/asn.2005070751.Peer-Reviewed Original ResearchRenalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Journal Of Clinical Investigation 2005, 115: 1275-1280. PMID: 15841207, PMCID: PMC1074681, DOI: 10.1172/jci24066.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseBlood pressureRenal diseaseCardiac functionNovel flavin adenine dinucleotide-dependent amine oxidaseFlavin adenine dinucleotide-dependent amine oxidaseSystemic blood pressurePeripheral vascular toneRenalase gene expressionCardiovascular morbiditySoluble monoamine oxidaseVascular toneAvailable therapiesPlasma concentrationsCardiac contractilityEndocrine functionEndocrine organHealthy subjectsHeart rateElectrolyte balanceCompensatory increaseSmall intestineKidneyRenalaseMonoamine oxidase