2014
Renalase regulates peripheral and central dopaminergic activities
Quelhas-Santos J, Serrão MP, Soares-Silva I, Fernandes-Cerqueira C, Simões-Silva L, Pinho MJ, Remião F, Sampaio-Maia B, Desir GV, Pestana M. Renalase regulates peripheral and central dopaminergic activities. American Journal Of Physiology. Renal Physiology 2014, 308: f84-f91. PMID: 25411385, PMCID: PMC4338928, DOI: 10.1152/ajprenal.00274.2014.Peer-Reviewed Original ResearchConceptsKO miceUrinary excretionPlasma levelsDopaminergic activityIncreased Plasma LevelsPeripheral dopaminergic activityUrine catecholamine levelsRenal dopaminergic systemCentral dopaminergic activityL-type amino acid transporterWild-type miceAmino acid decarboxylase activityKnockout mouse modelRenalase deficiencyCatecholamine levelsDA outputUrinary dopamineAADC activityDopaminergic systemRenal cortexMouse modelDOPA ratioVivo administrationOverexpression of LAT1Amino acid transportersRenalase Prevents AKI Independent of Amine Oxidase Activity
Wang L, Velazquez H, Moeckel G, Chang J, Ham A, Lee HT, Safirstein R, Desir GV. Renalase Prevents AKI Independent of Amine Oxidase Activity. Journal Of The American Society Of Nephrology 2014, 25: 1226-1235. PMID: 24511138, PMCID: PMC4033373, DOI: 10.1681/asn.2013060665.Peer-Reviewed Original ResearchConceptsIschemic injuryCatecholamine levelsRecombinant renalaseAmine oxidase activityHuman proximal tubular cellsCisplatin-induced AKITreatment of AKIWild-type miceHK-2 cellsProximal tubular cellsOxidase activityKidney injuryRenal injuryC-Jun N-terminal kinaseExtracellular signal-regulated kinaseP38 mitogen-activated protein kinaseToxic injuryRenalase proteinTubular cellsSignal-regulated kinaseIntracellular signaling cascadesRenalaseInjuryMitogen-activated protein kinaseN-terminal kinase
2013
Renalase Protects against Ischemic AKI
Lee HT, Kim JY, Kim M, Wang P, Tang L, Baroni S, D’Agati V, Desir GV. Renalase Protects against Ischemic AKI. Journal Of The American Society Of Nephrology 2013, 24: 445-455. PMID: 23393318, PMCID: PMC3582209, DOI: 10.1681/asn.2012090943.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdrenergic alpha-AntagonistsAnimalsApoptosisGene ExpressionHumansInflammation MediatorsIschemiaKidney Tubular Necrosis, AcuteMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMonoamine OxidaseNeutrophil InfiltrationNorepinephrinePhentolamineRecombinant ProteinsReperfusion InjuryRNA, MessengerConceptsRenal ischemia-reperfusion injuryIschemia-reperfusion injuryIschemic AKIWild-type miceReperfusion injuryCatecholamine levelsRenal tubular inflammationTreatment of AKIRenal ischemia reperfusionSham-operated micePlasma catecholamine levelsRenal tubular necrosisRecombinant human renalasePlasma renalaseTubular inflammationTubular necrosisIschemia reperfusionNE levelsPlasma catecholaminesMyocardial necrosisInflammatory responseProximal tubulesAKIRenalaseMice
2011
Novel insights into the physiology of renalase and its role in hypertension and heart disease
Desir G. Novel insights into the physiology of renalase and its role in hypertension and heart disease. Pediatric Nephrology 2011, 27: 719-725. PMID: 21424526, DOI: 10.1007/s00467-011-1828-7.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseResistant hypertensionSympathetic toneBlood pressureRecombinant renalaseSpontaneously Hypertensive Stroke-PronePlasma renalase levelsRenalase knockout mouseSystolic blood pressureModel of hypertensionPotent antihypertensive agentSevere cardiac hypertrophyRenalase deficiencyRenalase levelsRenal functionUrine catecholaminesEssential hypertensionSalt intakeStroke proneAntihypertensive agentsCatecholamine levelsRenal sodiumSingle dosePlasma levels
2010
Renalase deficiency aggravates ischemic myocardial damage
Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV. Renalase deficiency aggravates ischemic myocardial damage. Kidney International 2010, 79: 853-860. PMID: 21178975, DOI: 10.1038/ki.2010.488.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseWild-type miceRenalase deficiencyKnockout micePlasma blood urea nitrogenLevels of renalaseMild ventricular hypertrophyRenalase knockout mouseNormal systolic functionTraditional risk factorsPlasma catecholamine levelsIschemic myocardial damageBlood urea nitrogenCardiac complicationsCardiovascular complicationsSystolic functionVentricular hypertrophyCardioprotective effectsCatecholamine levelsKidney diseaseMyocardial damageMyocardial necrosisRecombinant renalaseRisk factorsCardiac ischemia
2008
Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase
Li G, Xu J, Wang P, Velazquez H, Li Y, Wu Y, Desir GV. Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase. Circulation 2008, 117: 1277-1282. PMID: 18299506, DOI: 10.1161/circulationaha.107.732032.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseExcess catecholaminesPlasma renalase concentrationSystolic pressure increaseSympathetic nervous systemRenalase gene expressionRegulation of catecholaminesAttractive therapeutic modalityRenalase concentrationCatecholamine surgeBlood pressureNormotensive ratsCatecholamine levelsHemodynamic changesPlasma levelsRecombinant renalaseSystemic abnormalitiesRenalase activityCardiac contractilityTherapeutic modalitiesCardiac hypertrophyCatecholamine metabolismHeart rateParenteral administration
2007
Renalase is a novel renal hormone that regulates cardiovascular function
Desir GV. Renalase is a novel renal hormone that regulates cardiovascular function. International Journal Of Cardiology Cardiovascular Risk And Prevention 2007, 1: 99-103. PMID: 20409839, DOI: 10.1016/j.jash.2006.12.001.Peer-Reviewed Original ResearchChronic kidney diseaseRenal hormoneBlood pressureKidney diseaseBlood levelsFlavin adenine dinucleotide-dependent amine oxidaseEnd-stage renal diseaseRenal replacement therapySystemic blood pressurePeripheral vascular toneCardiovascular morbidityCardiovascular outcomesSympathetic toneRenal diseaseCatecholamine levelsReplacement therapyVascular tonePatient populationCardiac functionDiseased kidneysCardiovascular functionCardiac contractilityHealthy subjectsHeart rateCompensatory increase