2014
Renalase regulates peripheral and central dopaminergic activities
Quelhas-Santos J, Serrão MP, Soares-Silva I, Fernandes-Cerqueira C, Simões-Silva L, Pinho MJ, Remião F, Sampaio-Maia B, Desir GV, Pestana M. Renalase regulates peripheral and central dopaminergic activities. American Journal Of Physiology. Renal Physiology 2014, 308: f84-f91. PMID: 25411385, PMCID: PMC4338928, DOI: 10.1152/ajprenal.00274.2014.Peer-Reviewed Original ResearchConceptsKO miceUrinary excretionPlasma levelsDopaminergic activityIncreased Plasma LevelsPeripheral dopaminergic activityUrine catecholamine levelsRenal dopaminergic systemCentral dopaminergic activityL-type amino acid transporterWild-type miceAmino acid decarboxylase activityKnockout mouse modelRenalase deficiencyCatecholamine levelsDA outputUrinary dopamineAADC activityDopaminergic systemRenal cortexMouse modelDOPA ratioVivo administrationOverexpression of LAT1Amino acid transporters
2013
Renalase regulates renal dopamine and phosphate metabolism
Sizova D, Velazquez H, Sampaio-Maia B, Quelhas-Santos J, Pestana M, Desir GV. Renalase regulates renal dopamine and phosphate metabolism. American Journal Of Physiology. Renal Physiology 2013, 305: f839-f844. PMID: 23863468, PMCID: PMC3761288, DOI: 10.1152/ajprenal.00616.2012.Peer-Reviewed Original ResearchConceptsRenal DA synthesisKO micePO4 excretionDA synthesisSodium-phosphate cotransporter Npt2aCatecholamine-degrading enzymeIntrinsic renal defectRenal dopamine synthesisWild-type miceKO mice showKnockout mouse modelDopa excretionRenalase deficiencySevere hypophosphatemiaRenal dopamineSerum PO4Urinary dopaminePhosphate excretionRegular dietDietary phosphateDopamine synthesisMouse modelMice showCompensatory increaseRenal defects
2011
Role of renalase in the regulation of blood pressure and the renal dopamine system
Desir GV. Role of renalase in the regulation of blood pressure and the renal dopamine system. Current Opinion In Nephrology & Hypertension 2011, 20: 31-36. PMID: 21099685, DOI: 10.1097/mnh.0b013e3283412721.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseDahl salt-sensitive ratsRenal dopamine systemSalt-sensitive ratsRenalase deficiencyBlood pressureKidney diseaseRenalase levelsResistant hypertensionRecombinant renalaseDopamine systemProximal tubular sodium transportStable coronary artery diseaseComparable blood pressurePlasma renalase levelsRole of renalaseMechanisms of hypertensionNormal renal functionTubular sodium transportCoronary artery diseaseElevation of plasmaPotent antihypertensive agentSevere cardiac hypertrophyKnockout mouse modelRenalase expression