2014
Renalase
Guo X, Wang L, Velazquez H, Safirstein R, Desir GV. Renalase. Current Opinion In Nephrology & Hypertension 2014, 23: 513-518. PMID: 24992568, PMCID: PMC4383282, DOI: 10.1097/mnh.0000000000000044.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsEnzymatic functionType 1 diabetesMitogen-activated protein kinase pathwayNucleotide polymorphismsProtein kinase BProtein kinase pathwayCellular actionsPlasma membraneKinase pathwayKinase BPotential therapeutic utilityCertain single nucleotide polymorphismsEnzymatic propertiesIschemic strokeImmune modulatorsRenalase geneTherapeutic utilityCytoprotective effectsClinical implicationsRenalaseConsistent associationPotential roleDiabetesCytokines
2010
Role of Novel Biomarkers in Chronic Kidney Disease: Renalase
Desir G. Role of Novel Biomarkers in Chronic Kidney Disease: Renalase. 2010, 309-316. DOI: 10.1007/978-88-470-1463-3_24.Peer-Reviewed Original ResearchChronic kidney diseaseBlood pressureKidney diseaseCardiac functionRenalase knockout mouseAcute kidney injurySevere cardiovascular complicationsCardiovascular complicationsKidney injuryEssential hypertensionCardiac injuryMyocardial injuryEarly biomarkersRenalase geneNovel biomarkersKnockout miceTherapeutic utilityRenalaseInjuryProtein expressionSingle nucleotide polymorphismsPreliminary dataDiseaseModest increaseBiomarkers
2009
Regulation of blood pressure and cardiovascular function by renalase
Desir GV. Regulation of blood pressure and cardiovascular function by renalase. Kidney International 2009, 76: 366-370. PMID: 19471322, DOI: 10.1038/ki.2009.169.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseGlomerular filtration rateBlood pressureKidney diseasePlasma catecholaminesCardiovascular functionKnockout miceEnd-stage kidney diseaseRenalase knockout mouseSingle nucleotide polymorphismsRenalase levelsCardiovascular riskEssential hypertensionFiltration rateCardiac functionCardiac ischemiaRenalase geneSignificant fallAnimal modelsRenalaseCatecholaminesHypertensionPatientsFold stimulationAbnormalities
2007
Renalase, a new renal hormone: its role in health and disease
Xu J, Desir GV. Renalase, a new renal hormone: its role in health and disease. Current Opinion In Nephrology & Hypertension 2007, 16: 373-378. PMID: 17565281, DOI: 10.1097/mnh.0b013e3281bd8877.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseEnd-stage renal diseaseKidney diseaseBlood pressureRenal hormoneRenal diseaseSalt-sensitive Dahl ratsExaggerated blood pressure responseBaseline blood pressureBlood pressure responseSympathetic nervous systemImportant therapeutic modalityRenalase deficiencyCardiovascular riskDahl ratsEssential hypertensionPlasma levelsCardiac functionRecombinant renalaseCardiovascular functionCardiovascular diseaseTherapeutic modalitiesHeart rateRenalase geneAdrenergic stress