2007
Renalase is a novel renal hormone that regulates cardiovascular function
Desir GV. Renalase is a novel renal hormone that regulates cardiovascular function. International Journal Of Cardiology Cardiovascular Risk And Prevention 2007, 1: 99-103. PMID: 20409839, DOI: 10.1016/j.jash.2006.12.001.Peer-Reviewed Original ResearchChronic kidney diseaseRenal hormoneBlood pressureKidney diseaseBlood levelsFlavin adenine dinucleotide-dependent amine oxidaseEnd-stage renal diseaseRenal replacement therapySystemic blood pressurePeripheral vascular toneCardiovascular morbidityCardiovascular outcomesSympathetic toneRenal diseaseCatecholamine levelsReplacement therapyVascular tonePatient populationCardiac functionDiseased kidneysCardiovascular functionCardiac contractilityHealthy subjectsHeart rateCompensatory increase
2005
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Journal Of Clinical Investigation 2005, 115: 1275-1280. PMID: 15841207, PMCID: PMC1074681, DOI: 10.1172/jci24066.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseBlood pressureRenal diseaseCardiac functionNovel flavin adenine dinucleotide-dependent amine oxidaseFlavin adenine dinucleotide-dependent amine oxidaseSystemic blood pressurePeripheral vascular toneRenalase gene expressionCardiovascular morbiditySoluble monoamine oxidaseVascular toneAvailable therapiesPlasma concentrationsCardiac contractilityEndocrine functionEndocrine organHealthy subjectsHeart rateElectrolyte balanceCompensatory increaseSmall intestineKidneyRenalaseMonoamine oxidase
2002
Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.
Yao X, Tian S, Chan HY, Biemesderfer D, Desir GV. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. Journal Of The American Society Of Nephrology 2002, 13: 2831-9. PMID: 12444201, DOI: 10.1097/01.asn.0000036866.37886.c5.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsProximal tubular cellsSmooth muscle cellsApical membraneImportant cellular functionsSitu hybridization experimentsVascular toneVoltage-activated K channelsTubular cellsMuscle cellsImmunocytochemical studyCellular functionsHuman proximal tubular cellsRat proximal tubular cellsSubcellular localizationHybridization experimentsVoltage-gated K channelsK channelsNorthern blotRenal proximal tubulesCell membrane voltageVascular endothelial cellsKCNA10Cell membrane potentialVascular tissue