Renalase deficiency aggravates ischemic myocardial damage
Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV. Renalase deficiency aggravates ischemic myocardial damage. Kidney International 2010, 79: 853-860. PMID: 21178975, DOI: 10.1038/ki.2010.488.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseWild-type miceRenalase deficiencyKnockout micePlasma blood urea nitrogenLevels of renalaseMild ventricular hypertrophyRenalase knockout mouseNormal systolic functionTraditional risk factorsPlasma catecholamine levelsIschemic myocardial damageBlood urea nitrogenCardiac complicationsCardiovascular complicationsSystolic functionVentricular hypertrophyCardioprotective effectsCatecholamine levelsKidney diseaseMyocardial damageMyocardial necrosisRecombinant renalaseRisk factorsCardiac ischemiaA Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study
Farzaneh-Far R, Desir GV, Na B, Schiller NB, Whooley MA. A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study. PLOS ONE 2010, 5: e13496. PMID: 20975995, PMCID: PMC2958117, DOI: 10.1371/journal.pone.0013496.Peer-Reviewed Original ResearchConceptsPoor exercise capacityExercise capacityInducible ischemiaCardiac hypertrophyDiastolic dysfunctionSystolic dysfunctionStable coronary artery diseaseMissense polymorphismTreadmill exercise capacityCoronary artery diseaseSoul StudyVentricular dysfunctionArtery diseaseVentricular hypertrophyStress echocardiographyCommon missense polymorphismCC genotypeIschemiaTherapeutic implicationsCG genotypeCardiac structureDysfunctionHypertrophyRenalaseLogistic regression