1999
Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman’s syndrome
Kunchaparty S, Palcso M, Berkman J, Velázquez H, Desir G, Bernstein P, Reilly R, Ellison D. Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman’s syndrome. American Journal Of Physiology 1999, 277: f643-f649. PMID: 10516289, DOI: 10.1152/ajprenal.1999.277.4.f643.Peer-Reviewed Original ResearchConceptsWild-type cloneTransport proteinsWild-type proteinWild-type geneUnglycosylated proteinProtein processingNa-Cl cotransporterUnglycosylated formEndoplasmic reticulumMutant clonesFunctional expressionDisease mutationsDefective processingXenopus oocytesProteinClonesThiazide-sensitive Na-Cl cotransporterSodium uptakeMutationsOocytesMembrane stainingAutosomal recessive disorderWestern blot
1993
Immunocytochemical characterization of the high-affinity thiazide diuretic receptor in rabbit renal cortex
Ellison DH, Biemesderfer D, Morrisey J, Lauring J, Desir GV. Immunocytochemical characterization of the high-affinity thiazide diuretic receptor in rabbit renal cortex. American Journal Of Physiology 1993, 264: f141-f148. PMID: 8430824, DOI: 10.1152/ajprenal.1993.264.1.f141.Peer-Reviewed Original ResearchConceptsThiazide diuretic receptorRenal distal tubulesDistal tubulesUrinary NaCl excretionRenal cortical membranesThick ascending limbRabbit kidney cortexApical membraneThiazide diureticsRenal cortexRabbit renal cortexCortical membranesProximal tubulesAscending limbSubpopulation of cellsNaCl excretionThiazide receptorKidney cortexIntense stainingWestern blotMonoclonal antibodiesRabbit kidneyImmunocytochemical characterizationPrincipal cellsReceptors