2021
Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease
Pointer TC, Gorelick FS, Desir GV. Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease. Cells 2021, 10: 2006. PMID: 34440775, PMCID: PMC8391834, DOI: 10.3390/cells10082006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGastrointestinal DiseasesGastrointestinal TractHumansMonoamine OxidaseProtein IsoformsSignal TransductionConceptsProsurvival effectAcute cerulein pancreatitisRole of renalaseAnti-inflammatory effectsDisease modelsAcute organ injuryRelevant clinical settingsShortens life expectancyPreclinical disease modelsCell survivalHuman cancer tissuesCancer cell survivalOrgan injuryAcute injuryPancreatic cancerIntestinal diseaseGastrointestinal diseasesRodent modelsCerulein pancreatitisSelect cancersCancer tissuesRenalaseClinical settingTherapeutic agentsExport transporters
2016
Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism
Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C, Desir G. Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer Research 2016, 76: 3884-3894. PMID: 27197188, PMCID: PMC5031238, DOI: 10.1158/0008-5472.can-15-1524.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkers, TumorBlotting, WesternCase-Control StudiesCell CycleCell ProliferationFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHumansImmunoenzyme TechniquesMacrophagesMaleMelanomaMiceMice, Inbred C57BLMice, NudeMonoamine OxidaseNeoplasm StagingP38 Mitogen-Activated Protein KinasesPrognosisProto-Oncogene Proteins c-aktSignal TransductionSTAT3 Transcription FactorSurvival RateTumor Cells, CulturedXenograft Model Antitumor AssaysConceptsTumor-associated macrophagesDisease-specific survivalManagement of melanomaPotential therapeutic implicationsCell cycle inhibitor p21Melanoma cell growthPI3K/AktMelanoma cell survivalCell growth arrestPathogenic rolePrimary melanomaToxic injuryMurine xenograftsTherapeutic implicationsTumor growthClinical specimensRenalaseBax activationTumor microenvironmentTumor cellsInhibitor p21Growth arrestSurvival factorElevated expressionMAPK pathwayA Remote Role for Renalase
Giordano FJ, Wang Y, Desir GV. A Remote Role for Renalase. EBioMedicine 2016, 9: 27-28. PMID: 27374133, PMCID: PMC4972559, DOI: 10.1016/j.ebiom.2016.06.034.Peer-Reviewed Original ResearchInhibition of renalase expression and signaling has antitumor activity in pancreatic cancer
Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, Safirstein R, Cha C, Gorelick F, Desir GV. Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer. Scientific Reports 2016, 6: 22996. PMID: 26972355, PMCID: PMC4789641, DOI: 10.1038/srep22996.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnimalsAntibodiesApoptosisCarcinoma, Pancreatic DuctalCell Cycle CheckpointsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryKaplan-Meier EstimateMaleMice, NudeMiddle AgedMonoamine OxidasePancreatic NeoplasmsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReverse Transcriptase Polymerase Chain ReactionRNA InterferenceSignal TransductionXenograft Model Antitumor AssaysConceptsRenalase expressionPancreatic cancerPancreatic ductal adenocarcinoma growthCohort of patientsPancreatic cancer tissuesPancreatic ductal adenocarcinomaPancreatic ductal adenocarcinoma cellsXenograft mouse modelAttractive therapeutic targetDuctal adenocarcinoma cellsTumor cell apoptosisOverall survivalPathogenic roleCell cycle arrestDuctal adenocarcinomaPrognostic makerTumor massMouse modelTherapeutic targetCellular injuryCancer tissuesRenalaseCancerAdenocarcinoma cellsGrowth factor
2015
Identification of a Receptor for Extracellular Renalase
Wang L, Velazquez H, Chang J, Safirstein R, Desir GV. Identification of a Receptor for Extracellular Renalase. PLOS ONE 2015, 10: e0122932. PMID: 25906147, PMCID: PMC4407985, DOI: 10.1371/journal.pone.0122932.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryCell LineCytoprotectionDown-RegulationEpidermal Growth FactorEssential HypertensionHumansHypertensionMitogen-Activated Protein KinasesMonoamine OxidasePlasma Membrane Calcium-Transporting ATPasesPolymorphism, Single NucleotideProtein Interaction Domains and MotifsSignal TransductionConceptsAcute kidney injuryIntrinsic enzymatic activityMAPK signalingExtracellular renalaseHuman proximal tubular cell line HK-2Enzymatic activitySingle nucleotide gene polymorphismsAcute ischemic kidneyWild-type miceProtein-protein interactionsPlasma membrane ATPaseKidney injuryIschemic kidneyEssential hypertensionIschemic injuryCardiac injuryPMCA4b expressionRecombinant renalaseEpidermal growth factorType miceCardiac hypertrophyHK-2Control studyGene polymorphismsCell signaling
2014
Renalase
Guo X, Wang L, Velazquez H, Safirstein R, Desir GV. Renalase. Current Opinion In Nephrology & Hypertension 2014, 23: 513-518. PMID: 24992568, PMCID: PMC4383282, DOI: 10.1097/mnh.0000000000000044.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsEnzymatic functionType 1 diabetesMitogen-activated protein kinase pathwayNucleotide polymorphismsProtein kinase BProtein kinase pathwayCellular actionsPlasma membraneKinase pathwayKinase BPotential therapeutic utilityCertain single nucleotide polymorphismsEnzymatic propertiesIschemic strokeImmune modulatorsRenalase geneTherapeutic utilityCytoprotective effectsClinical implicationsRenalaseConsistent associationPotential roleDiabetesCytokines
2011
Increased renal dopamine and acute renal adaptation to a high-phosphate diet
Weinman EJ, Biswas R, Steplock D, Wang P, Lau YS, Desir GV, Shenolikar S. Increased renal dopamine and acute renal adaptation to a high-phosphate diet. American Journal Of Physiology. Renal Physiology 2011, 300: f1123-f1129. PMID: 21325500, PMCID: PMC3094044, DOI: 10.1152/ajprenal.00744.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnalysis of VarianceAnimalsAromatic Amino Acid Decarboxylase InhibitorsCarbidopaCyclic AMP-Dependent Protein KinasesDopa DecarboxylaseDopamineEnzyme InhibitorsKidneyMaleMiceMice, Inbred C57BLMonoamine OxidasePhosphorus, DietaryProtein Kinase CRatsRats, Sprague-DawleySignal TransductionTime FactorsUp-RegulationConceptsHigh-phosphate dietLow-phosphate dietPhosphate excretionDopamine contentRenal dopamine receptorsRenal phosphate excretionRenal tubular reabsorptionTreatment of ratsMarkers of activationRole of dopamineRenal dopamineUrinary excretionTubular reabsorptionRenal adaptationTwo- to threefold increaseAcute increaseMonoamine oxidase ADopamine receptorsDopamine synthesisImpaired adaptation