2022
Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study
Wang Y, Zhao P, Chu C, Du MF, Zhang XY, Zou T, Hu GL, Zhou HW, Jia H, Liao YY, Chen C, Ma Q, Wang D, Yan Y, Sun Y, Wang KK, Niu ZJ, Zhang X, Man ZY, Wu YX, Wang L, Li HX, Zhang J, Li CH, Gao WH, Gao K, Lu WH, Desir GV, Delles C, Chen FY, Mu JJ. Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study. Hypertension 2022, 79: 1247-1256. PMID: 35360932, PMCID: PMC9093226, DOI: 10.1161/hypertensionaha.121.18658.Peer-Reviewed Original ResearchConceptsLong-term blood pressure variabilitySubclinical kidney damageAverage real variabilityBlood pressure variabilityLong-term visitCreatinine ratioUrinary albuminMean BPKidney damageCardiovascular diseasePressure variabilityHigh riskCumulative exposureHanzhong Adolescent Hypertension StudyVisit blood pressure variabilityProspective cohort studyGlomerular filtration rateRisk of albuminuriaClinical characteristicsCohort studyOngoing cohortKidney diseaseHypertension StudyFiltration rateAlbuminuria
2017
Extracellular renalase protects cells and organs by outside‐in signalling
Wang Y, Safirstein R, Velazquez H, Guo X, Hollander L, Chang J, Chen T, Mu J, Desir GV. Extracellular renalase protects cells and organs by outside‐in signalling. Journal Of Cellular And Molecular Medicine 2017, 21: 1260-1265. PMID: 28238213, PMCID: PMC5487909, DOI: 10.1111/jcmm.13062.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureCatecholaminesCytokinesHeart RateHumansKidneyMonoamine OxidaseNADPH OxidasesNeoplasmsOxidation-ReductionConceptsProtective effectNovel therapeutic strategiesCancer cell growthBlood pressureOrgan injuryJAK/STATHeart rateTherapeutic strategiesToxic injuryCytoprotective actionMitogen-activated protein kinase pathwayRenalaseTranslational opportunitiesTumor cellsCellular actionsProtein kinase BInitial reportProtein kinase pathwayInjuryKinase BOrgansKinase pathwayGrowth-related genesCell growthExtracellular renalase
2013
Renalase in hypertension and kidney disease
Desir GV, Peixoto AJ. Renalase in hypertension and kidney disease. Nephrology Dialysis Transplantation 2013, 29: 22-28. PMID: 24137013, DOI: 10.1093/ndt/gft083.Peer-Reviewed Original Research
2011
Role of renalase in the regulation of blood pressure and the renal dopamine system
Desir GV. Role of renalase in the regulation of blood pressure and the renal dopamine system. Current Opinion In Nephrology & Hypertension 2011, 20: 31-36. PMID: 21099685, DOI: 10.1097/mnh.0b013e3283412721.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseDahl salt-sensitive ratsRenal dopamine systemSalt-sensitive ratsRenalase deficiencyBlood pressureKidney diseaseRenalase levelsResistant hypertensionRecombinant renalaseDopamine systemProximal tubular sodium transportStable coronary artery diseaseComparable blood pressurePlasma renalase levelsRole of renalaseMechanisms of hypertensionNormal renal functionTubular sodium transportCoronary artery diseaseElevation of plasmaPotent antihypertensive agentSevere cardiac hypertrophyKnockout mouse modelRenalase expression
2010
The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis
Reilly RF, Peixoto AJ, Desir GV. The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis. Clinical Journal Of The American Society Of Nephrology 2010, 5: 1893-1903. PMID: 20798254, DOI: 10.2215/cjn.04670510.Peer-Reviewed Original ResearchConceptsUse of indapamideUrinary calcium excretionThiazide-type diureticsRandomized clinical trialsTreatment of hypertensionEvidence-based useDose-response effectPaucity of dataInitial therapyCalcium excretionHypertensive patientsOlder patientsThiazide diureticsStone recurrencePatient groupClinical trialsDrug classesSafe optionHypertensionDiureticsAvailable evidenceNephrolithiasisHydrochlorothiazideChlorthalidoneSafe track record
2009
Regulation of blood pressure and cardiovascular function by renalase
Desir GV. Regulation of blood pressure and cardiovascular function by renalase. Kidney International 2009, 76: 366-370. PMID: 19471322, DOI: 10.1038/ki.2009.169.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseGlomerular filtration rateBlood pressureKidney diseasePlasma catecholaminesCardiovascular functionKnockout miceEnd-stage kidney diseaseRenalase knockout mouseSingle nucleotide polymorphismsRenalase levelsCardiovascular riskEssential hypertensionFiltration rateCardiac functionCardiac ischemiaRenalase geneSignificant fallAnimal modelsRenalaseCatecholaminesHypertensionPatientsFold stimulationAbnormalities
2008
Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease
Desir GV. Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. Current Opinion In Nephrology & Hypertension 2008, 17: 181-185. PMID: 18277152, DOI: 10.1097/mnh.0b013e3282f521ba.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseBlood pressureAnimal modelsCardiac functionEnd-stage renal diseaseRegulation of renalaseSalt-dependent hypertensionDevelopment of hypertensionSystolic blood pressurePlasma renalaseRenalase deficiencyCatecholamine administrationSympathetic toneRenal diseaseKidney functionSubtotal nephrectomyPlasma catecholaminesCardiovascular diseaseHypertensionLower plasmaRenalaseCatecholaminesDiseaseAbnormalities
2007
Renalase, a new renal hormone: its role in health and disease
Xu J, Desir GV. Renalase, a new renal hormone: its role in health and disease. Current Opinion In Nephrology & Hypertension 2007, 16: 373-378. PMID: 17565281, DOI: 10.1097/mnh.0b013e3281bd8877.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureCatecholaminesHumansKidneyKidney Failure, ChronicMonoamine OxidaseSympathetic Nervous SystemConceptsChronic kidney diseaseEnd-stage renal diseaseKidney diseaseBlood pressureRenal hormoneRenal diseaseSalt-sensitive Dahl ratsExaggerated blood pressure responseBaseline blood pressureBlood pressure responseSympathetic nervous systemImportant therapeutic modalityRenalase deficiencyCardiovascular riskDahl ratsEssential hypertensionPlasma levelsCardiac functionRecombinant renalaseCardiovascular functionCardiovascular diseaseTherapeutic modalitiesHeart rateRenalase geneAdrenergic stress
2005
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Journal Of Clinical Investigation 2005, 115: 1275-1280. PMID: 15841207, PMCID: PMC1074681, DOI: 10.1172/jci24066.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureHumansKidneyLiverMonoamine OxidaseMuscle, SkeletalMyocardiumRatsRats, Sprague-DawleyConceptsEnd-stage renal diseaseBlood pressureRenal diseaseCardiac functionNovel flavin adenine dinucleotide-dependent amine oxidaseFlavin adenine dinucleotide-dependent amine oxidaseSystemic blood pressurePeripheral vascular toneRenalase gene expressionCardiovascular morbiditySoluble monoamine oxidaseVascular toneAvailable therapiesPlasma concentrationsCardiac contractilityEndocrine functionEndocrine organHealthy subjectsHeart rateElectrolyte balanceCompensatory increaseSmall intestineKidneyRenalaseMonoamine oxidase