2008
Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase
Li G, Xu J, Wang P, Velazquez H, Li Y, Wu Y, Desir GV. Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase. Circulation 2008, 117: 1277-1282. PMID: 18299506, DOI: 10.1161/circulationaha.107.732032.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseExcess catecholaminesPlasma renalase concentrationSystolic pressure increaseSympathetic nervous systemRenalase gene expressionRegulation of catecholaminesAttractive therapeutic modalityRenalase concentrationCatecholamine surgeBlood pressureNormotensive ratsCatecholamine levelsHemodynamic changesPlasma levelsRecombinant renalaseSystemic abnormalitiesRenalase activityCardiac contractilityTherapeutic modalitiesCardiac hypertrophyCatecholamine metabolismHeart rateParenteral administration
2005
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Journal Of Clinical Investigation 2005, 115: 1275-1280. PMID: 15841207, PMCID: PMC1074681, DOI: 10.1172/jci24066.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseBlood pressureRenal diseaseCardiac functionNovel flavin adenine dinucleotide-dependent amine oxidaseFlavin adenine dinucleotide-dependent amine oxidaseSystemic blood pressurePeripheral vascular toneRenalase gene expressionCardiovascular morbiditySoluble monoamine oxidaseVascular toneAvailable therapiesPlasma concentrationsCardiac contractilityEndocrine functionEndocrine organHealthy subjectsHeart rateElectrolyte balanceCompensatory increaseSmall intestineKidneyRenalaseMonoamine oxidase