2011
Novel insights into the physiology of renalase and its role in hypertension and heart disease
Desir G. Novel insights into the physiology of renalase and its role in hypertension and heart disease. Pediatric Nephrology 2011, 27: 719-725. PMID: 21424526, DOI: 10.1007/s00467-011-1828-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntihypertensive AgentsDopamineHeart DiseasesHumansHypertensionKidneyMiceMice, KnockoutMonoamine OxidaseMyocardial IschemiaRecombinant ProteinsSodium, DietaryConceptsChronic kidney diseaseKidney diseaseResistant hypertensionSympathetic toneBlood pressureRecombinant renalaseSpontaneously Hypertensive Stroke-PronePlasma renalase levelsRenalase knockout mouseSystolic blood pressureModel of hypertensionPotent antihypertensive agentSevere cardiac hypertrophyRenalase deficiencyRenalase levelsRenal functionUrine catecholaminesEssential hypertensionSalt intakeStroke proneAntihypertensive agentsCatecholamine levelsRenal sodiumSingle dosePlasma levels
2010
The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis
Reilly RF, Peixoto AJ, Desir GV. The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis. Clinical Journal Of The American Society Of Nephrology 2010, 5: 1893-1903. PMID: 20798254, DOI: 10.2215/cjn.04670510.Peer-Reviewed Original ResearchConceptsUse of indapamideUrinary calcium excretionThiazide-type diureticsRandomized clinical trialsTreatment of hypertensionEvidence-based useDose-response effectPaucity of dataInitial therapyCalcium excretionHypertensive patientsOlder patientsThiazide diureticsStone recurrencePatient groupClinical trialsDrug classesSafe optionHypertensionDiureticsAvailable evidenceNephrolithiasisHydrochlorothiazideChlorthalidoneSafe track record