1985
Effects of short‐term Cyclosporin‐A on biomechanical properties of intact and fractured bone in the rat
Warren S, Pelker R, Friedlaender G. Effects of short‐term Cyclosporin‐A on biomechanical properties of intact and fractured bone in the rat. Journal Of Orthopaedic Research® 1985, 3: 96-100. PMID: 3981300, DOI: 10.1002/jor.1100030112.Peer-Reviewed Original ResearchConceptsControl animalsSolid organ allograft survivalFracture repairCurrent biomechanical dataOrgan allograft survivalShort-term cyclosporinBiomechanical propertiesSolid organ transplantationEffect of cyclosporinShort-term clinical useMidshaft femoral fractureNew immunosuppressant drugsAllograft survivalFemoral fracturesBone turnoverRat modelSkeletal toxicityOrgan transplantationSystemic effectsHistomorphometric studyImmunosuppressant drugsIntramedullary pinBiologic effectsFractured femurCyclosporin
1984
Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model.
Friedlaender G, Tross R, Doganis A, Kirkwood J, Baron R. Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model. Journal Of Bone And Joint Surgery 1984, 66: 602-7. PMID: 6707039, DOI: 10.2106/00004623-198466040-00016.Peer-Reviewed Original ResearchConceptsChemotherapeutic agentsShort-term methotrexateThickness of osteoidShort-term administrationTrabecular bone volumeNumber of osteoclastsPhysiological bone turnoverWistar-Lewis ratsBone formation rateTotal bone massBone allograft incorporationRate of resorptionChronic treatmentBone turnoverNew bone formationTherapeutic dosesBone massUntreated ratsRat modelBone allograftBone volumeProximal tail vertebraeOsteoblastic activityDoxorubicin treatmentAdverse effects