1991
The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats
Huo M, Troiano N, Pelker R, Gundberg C, Friedlaender G. The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats. Journal Of Orthopaedic Research® 1991, 9: 383-390. PMID: 2010842, DOI: 10.1002/jor.1100090310.Peer-Reviewed Original ResearchConceptsControl animalsHistomorphometric parametersFracture repairUnilateral femur fracturesMature Sprague-Dawley ratsSerum osteocalcin levelsCyclo-oxygenase inhibitorSprague-Dawley ratsBone formation rateInfluence of ibuprofenOral doseFemur fracturesOsteocalcin levelsClinical practiceBone volumeBone remodelingInhibitory effectSignificant alterationsFracture biomechanicsRatsAnimalsTail vertebraePresent studyIbuprofenRepair
1984
Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model.
Friedlaender G, Tross R, Doganis A, Kirkwood J, Baron R. Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model. Journal Of Bone And Joint Surgery 1984, 66: 602-7. PMID: 6707039, DOI: 10.2106/00004623-198466040-00016.Peer-Reviewed Original ResearchConceptsChemotherapeutic agentsShort-term methotrexateThickness of osteoidShort-term administrationTrabecular bone volumeNumber of osteoclastsPhysiological bone turnoverWistar-Lewis ratsBone formation rateTotal bone massBone allograft incorporationRate of resorptionChronic treatmentBone turnoverNew bone formationTherapeutic dosesBone massUntreated ratsRat modelBone allograftBone volumeProximal tail vertebraeOsteoblastic activityDoxorubicin treatmentAdverse effects