1993
Effects of prefracture irradiation on the biomechanical parameters of fracture healing
Widmann R, Pelker R, Friedlaender G, Panjabi M, Peschel R. Effects of prefracture irradiation on the biomechanical parameters of fracture healing. Journal Of Orthopaedic Research® 1993, 11: 422-428. PMID: 8326449, DOI: 10.1002/jor.1100110315.Peer-Reviewed Original Research
1991
Postfracture irradiation effects on the biomechanical and histologic parameters of fracture healing
Brown R, Pelker R, Friedlaender G, Peschel R, Panjabi M. Postfracture irradiation effects on the biomechanical and histologic parameters of fracture healing. Journal Of Orthopaedic Research® 1991, 9: 876-882. PMID: 1919851, DOI: 10.1002/jor.1100090614.Peer-Reviewed Original ResearchConceptsFracture healingControl fracturesDelay groupMature Sprague-Dawley ratsClosed femoral fracturesLong-term resultsSprague-Dawley ratsContralateral intact femurFemoral fracturesHistologic parametersLocal irradiationFracture repairFractured femurRadiation exposureWeeksIntact femurBiomechanical propertiesRatsDeleterious effectsShort-term deleterious effectsFemurDaysFracturesHealingGroupThe influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats
Huo M, Troiano N, Pelker R, Gundberg C, Friedlaender G. The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats. Journal Of Orthopaedic Research® 1991, 9: 383-390. PMID: 2010842, DOI: 10.1002/jor.1100090310.Peer-Reviewed Original ResearchConceptsControl animalsHistomorphometric parametersFracture repairUnilateral femur fracturesMature Sprague-Dawley ratsSerum osteocalcin levelsCyclo-oxygenase inhibitorSprague-Dawley ratsBone formation rateInfluence of ibuprofenOral doseFemur fracturesOsteocalcin levelsClinical practiceBone volumeBone remodelingInhibitory effectSignificant alterationsFracture biomechanicsRatsAnimalsTail vertebraePresent studyIbuprofenRepair
1989
Allograft incorporation: A biomechanical evaluation in a rat model
Pelker R, McKay J, Troiano N, Panjabi M, Friedlaender G. Allograft incorporation: A biomechanical evaluation in a rat model. Journal Of Orthopaedic Research® 1989, 7: 585-589. PMID: 2786956, DOI: 10.1002/jor.1100070417.Peer-Reviewed Original ResearchConceptsLewis ratsLevel of freezingImmunologic responseSprague-Dawley rat femursRat modelImmune responseAllogeneic boneFresh allograftsOsteosynthesis siteBiomechanical evaluationBiomechanical testingBiologic responseSubsequent healingAllograftsRat femurRatsIntact boneBoneFemurSignificant levelsResponseTransplantationTransplantGraftWeeks
1975
A laboratory model for the study of the immunobiology of osteosarcoma
Friedlaender G, Mitchell M. A laboratory model for the study of the immunobiology of osteosarcoma. Cancer 1975, 36: 1631-1639. PMID: 172215, DOI: 10.1002/1097-0142(197511)36:5<1631::aid-cncr2820360516>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsCell-mediated immunityRegression of diseaseWistar-Lewis ratsMoloney sarcomasMoloney sarcoma virusProgressive diseaseClinical courseLung metastasesMicrocytotoxicity assayTreatment protocolImmune responseImmunologic similaritiesHuman osteosarcomaSerum factorsTumor cellsMarrow cavityOsteosarcomaTarget cellsRatsTumorsDiseaseSarcoma virusAnimalsWeeks of inoculationTissue culture