2001
Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions.
Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH, LaForte AJ, Yin S. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. Journal Of Bone And Joint Surgery 2001, 83-A Suppl 1: s151-8. PMID: 11314793, PMCID: PMC1425155, DOI: 10.2106/00004623-200100002-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone Morphogenetic Protein 7Bone Morphogenetic ProteinsBone TransplantationCollagenDrug CarriersDrug Delivery SystemsFemaleFracture Fixation, IntramedullaryFracture HealingFractures, UnunitedHumansMaleProspective StudiesRadiographyRecombinant ProteinsTibial FracturesTransforming Growth Factor betaConceptsTibial nonunionAdverse eventsRadiographic resultsClinical trialsOsteogenic protein-1Bone autograftAutogenous boneChronic donor site painAutograft-treated patientsFresh autogenous bonePlain radiographic evaluationMulti-center clinical trialPercent of patientsSeverity of painDonor site painGroup of patientsProtein 1Bone morphogenetic proteinNumerous animal modelsInvestigational device exemptionDonor site morbiditySame time pointsType ISite painClinical course
1997
The Nicolas Andry Award-1995 Fracture Healing; Radiation Induced Alterations
Pelker R, Friedlaender G. The Nicolas Andry Award-1995 Fracture Healing; Radiation Induced Alterations. Clinical Orthopaedics And Related Research® 1997, 341: 267-282. PMID: 9269183, DOI: 10.1097/00003086-199708000-00038.Peer-Reviewed Original ResearchConceptsIncidence of fracturesNonunion of fracturesDose fractionation schemesRadiation-Induced AlterationsNicolas Andry AwardSingle doseFractionation schemeClinical observationsAllogeneic boneFracture healingIrradiated boneControl groupFinal repairIncidenceInduced alterationsRat femur modelNonunionDegree of delayFracturesImmature levelBoneRepairEffects of radiationAnimalsRefracture